PUBLICATION
Hb-EGF directs systemic muscle repair
- Authors
- Dean, H.C., Saraswathy, V.M., Saini, A., Nachadalingam, S., McAdow, J., Tendolkar, A., Mokalled, M.H., Johnson, A.N.
- ID
- ZDB-PUB-260220-15
- Date
- 2026
- Source
- Development (Cambridge, England) 153: dev204993 (Journal)
- Registered Authors
- Mokalled, Mayssa
- Keywords
- Hb-EGF, Muscle regeneration, Regenerative capacity, Systemic muscle injury, Zebrafish
- MeSH Terms
- none
- PubMed
- 41717725 Full text @ Development
Citation
Dean, H.C., Saraswathy, V.M., Saini, A., Nachadalingam, S., McAdow, J., Tendolkar, A., Mokalled, M.H., Johnson, A.N. (2026) Hb-EGF directs systemic muscle repair. Development (Cambridge, England). 153:dev204993.
Abstract
Regenerative capacity varies between tissues, species, stages of the life cycle. Regenerative capacity also varies with the magnitude of the injury, even within a single tissue. Vertebrate skeletal muscle fully regenerates in response to small-scale injuries, but large-scale injuries often lead to incomplete repair and debilitating loss of muscle use. To understand if small- and large-scale muscle injuries activate distinct regenerative programs, we developed a systemic muscle injury model in zebrafish. Transcriptomic analysis of muscle and non-muscle tissues revealed that systemic and local muscle injuries elicit distinct molecular responses, both quantitatively and qualitatively. We found systemic muscle injury activates the expression of Heparin binding epidermal-like growth factor (Hb-EGF) in the epidermis, and Hb-EGF is necessary for systemic muscle repair. Conversely, local muscle injury did not induce Hb-EGF expression and Hb-EGF was not required for local muscle repair. These studies suggest that large- and small-scale muscle injuries activate different regenerative programs, resulting in either systemic or local repair.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping