PUBLICATION
Dietary nisin exacerbates diabetic vascular complications through gut microbiota modulation and NF-κB signaling
- Authors
- Liu, L., Huang, Y., Xu, H., Sun, Y., Xu, Z.Z., Huang, X.
- ID
- ZDB-PUB-260129-28
- Date
- 2026
- Source
- Ecotoxicology and environmental safety 309: 119638119638 (Journal)
- Registered Authors
- Keywords
- Diabetic vascular complications, Gut microbiota, Inflammation, NF-κB, Nisin, Oxidative stress, Zebrafish
- MeSH Terms
-
- Animals
- Diabetic Angiopathies*/chemically induced
- Dysbiosis/chemically induced
- Gastrointestinal Microbiome*/drug effects
- NF-kappa B*/metabolism
- Nisin*/adverse effects
- Nisin*/toxicity
- Oxidative Stress/drug effects
- Signal Transduction/drug effects
- Zebrafish
- PubMed
- 41601065 Full text @ Ecotoxicol. Environ. Saf.
Citation
Liu, L., Huang, Y., Xu, H., Sun, Y., Xu, Z.Z., Huang, X. (2026) Dietary nisin exacerbates diabetic vascular complications through gut microbiota modulation and NF-κB signaling. Ecotoxicology and environmental safety. 309:119638119638.
Abstract
Diabetic vascular complications (DVCs) are a major cause of morbidity in diabetes, with gut microbiota dysbiosis emerging as an important contributor. This study investigates the impact of nisin, a widely used food preservative, on DVCs using a zebrafish model. We found that nisin exacerbates diabetic vascular pathology in zebrafish through gut microbiota-dependent mechanisms. Nisin treatment induced dysbiosis with enrichment of Gram-negative pathogens and intestinal barrier disruption. Concurrently, it elevated systemic oxidative stress and pro-inflammatory cytokines, accompanied by NF-κB pathway activation. Germ-free zebrafish experiments confirmed the gut microbiota's essential role in nisin-induced vascular injury. Pharmacological inhibition of NF-κB reversed nisin's effects, restoring endothelial function and hemodynamics. Our findings reveal a previously unrecognized risk of nisin consumption in diabetic individuals and highlight the gut-vascular axis as a therapeutic target for DVCs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping