PUBLICATION
Emergence of a Potent AChE Inhibitor with Antioxidant and Neuroprotection Abilities
- Authors
- Osama, A., Ji, M., Fang, J., Zhao, H., Zhang, B.
- ID
- ZDB-PUB-260114-6
- Date
- 2025
- Source
- ACS Medicinal Chemistry Letters 17: 137143137-143 (Other)
- Registered Authors
- Keywords
- Alzheimer’s disease, acetylcholinesterase, antioxidant, neuroprotection
- MeSH Terms
- none
- PubMed
- 41531953 Full text @ ACS Med. Chem. Lett.
Citation
Osama, A., Ji, M., Fang, J., Zhao, H., Zhang, B. (2025) Emergence of a Potent AChE Inhibitor with Antioxidant and Neuroprotection Abilities. ACS Medicinal Chemistry Letters. 17:137143137-143.
Abstract
Oxidative damage and cholinergic dysfunction are common pathological features of Alzheimer's disease (AD). Maintaining the redox balance of neurons and cholinergic signaling through antioxidants and acetylcholinesterase (AChE) inhibition may provide therapeutic benefits for AD. In this regard, we discovered three AChE inhibitors with more potency than the positive control (rivastigmine; IC50 = 24.5 μM). Among these active compounds, C5 (a flavonoid derivative) was the most potent AChE inhibitor with an IC50 of 5.02 μM, followed by C1, C6, and C2 with IC50 values of 7.94 μM, 8.13 μM, and 27.52 μM, respectively. Compound C5 also demonstrated strong neuroprotective activity, rescuing PC12 cells from H2O2-induced damage and scavenging various ROS models. Interestingly, C5 also prevented memory impairments in the scopolamine-induced cognitive dysfunction zebrafish model. Our findings suggest that C5 is a potential drug lead for cholinergic dysfunction-related disorders such as AD.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping