PUBLICATION
Multidisciplinary Bioanalytical Approach to Assess the Anti-Aging Properties of Flower Petals-A Promising Sustainable Cosmetic Ingredient
- Authors
- Ivković, Đ., Senćanski, M., Novković, M., Stojković-Filipović, J., Trifković, J., Ristivojević, P., Krstić Ristivojević, M.
- ID
- ZDB-PUB-250927-29
- Date
- 2025
- Source
- Plants (Basel, Switzerland) 14: (Journal)
- Registered Authors
- Keywords
- anti-aging, cultivated petals, high performance thin layer chromatography (HPTLC), liquid chromatography coupled mass spectrometry (LC-MS), molecular docking, phenolic profiling, sustainable cosmetics
- MeSH Terms
- none
- PubMed
- 41012020 Full text @ Plants (Basel)
Citation
Ivković, Đ., Senćanski, M., Novković, M., Stojković-Filipović, J., Trifković, J., Ristivojević, P., Krstić Ristivojević, M. (2025) Multidisciplinary Bioanalytical Approach to Assess the Anti-Aging Properties of Flower Petals-A Promising Sustainable Cosmetic Ingredient. Plants (Basel, Switzerland). 14:.
Abstract
The increasing demand for natural, safe, and sustainable ingredients is driving innovation in cosmetic science. This study assessed the anti-aging potential of 17 petal extracts using a multidisciplinary bioanalytical approach. In vitro spectrophotometric assays evaluated anti-wrinkle (anti-elastase), anti-pigmentation (anti-tyrosinase), and antioxidant (DPPH, ABTS) activities, while cytotoxicity was tested on HaCaT keratinocytes. Chemical profiling using HPTLC and UHPLC-MS/MS identified 17 phenolic compounds. For the first time, petals from prairie rose (Rosa setigera Michx.), common peony (Paeonia officinalis L.), horse-chestnut cultivars (Aesculus hippocastanum L., Aesculus × carnea Zeyx.), lilac (Syringa vulgaris), mock-orange (Philadelphus pubescens Loisel), orange lily (Lilium bulbiferum L.), garden tulip (Tulipa gesneriana L.), ivy geranium (Pelargonium × peltatum (L.) L'Hér. ex Aiton), and wallflower (Erysimum × cheiri (L.) Crantz) were studied for their skin anti-aging properties. Prairie rose, peony, and ivy geranium extracts showed strong anti-elastase activity; rose and peony also demonstrated high antioxidant potential, while lilac exhibited significant anti-tyrosinase effects. Key phenolic constituents-caffeic acid, p-coumaric acid, and gallic acid-were further examined via molecular docking, which confirmed their inhibitory properties by revealing inhibition mechanisms. All extracts were confirmed to be non-toxic in zebrafish acute toxicity assays at relevant concentrations. This integrative strategy effectively links chemical composition with biological activity, offering valuable insight into the development of safe, plant-derived anti-aging agents for sustainable cosmetic applications.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping