PUBLICATION
Harnessing zebrafish as a model for photopharmacology: Insights into light-controlled biological effects of photoswitchable drugs
- Authors
- da Silva, G.P., Doorduin, J., Szymanski, W., da Silva, R.S., Elsinga, P., Bonan, C.D.
- ID
- ZDB-PUB-250918-6
- Date
- 2025
- Source
- Drug discovery today : 104477104477 (Review)
- Registered Authors
- Keywords
- molecular photoswitches, photopharmacology, pre-clinical translation models, zebrafish
- MeSH Terms
- none
- PubMed
- 40962200 Full text @ Drug Discov. Today
Citation
da Silva, G.P., Doorduin, J., Szymanski, W., da Silva, R.S., Elsinga, P., Bonan, C.D. (2025) Harnessing zebrafish as a model for photopharmacology: Insights into light-controlled biological effects of photoswitchable drugs. Drug discovery today. :104477104477. Epub ahead of print.
Abstract
Photopharmacology is an emerging field of pharmacological sciences that enables precise spatiotemporal control over drug activation with light. In its reversible mode, it relies on photoswitchable bioactive compounds. The capacity to reversibly activate and deactivate drugs derivatized with photoswitches enables us to avoid side effects and environmental toxicity. Zebrafish represent an emerging and privileged model for translational photopharmacology because of their optical transparency at early developmental stages, genetic tractability, and well-characterized biological mechanisms. In this review, we discuss the use of zebrafish in advancing photopharmacology and understanding the effects of light-controlled interventions using photoswitchable bioactive compounds.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping