PUBLICATION
Alterations of slitrk5a induce OCD-like "checking behaviors" in zebrafish
- Authors
- Sempowski, B.A., Woolford, K.R., Bouhussein, J., Lom, B.
- ID
- ZDB-PUB-250805-2
- Date
- 2025
- Source
- microPublication. Biology 2025: (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 40756281 Full text @ MicroPubl Biol
Citation
Sempowski, B.A., Woolford, K.R., Bouhussein, J., Lom, B. (2025) Alterations of slitrk5a induce OCD-like "checking behaviors" in zebrafish. microPublication. Biology. 2025:.
Abstract
The six transmembrane SLITRK proteins differentially regulate important aspects of neuronal development and function. Variants in SLITRK5 have been associated with complex neuropsychiatric conditions including obsessive compulsive disorder (OCD) and Slitrk5 knockout mice exhibit overgrooming and anxiety-like behaviors. This study generated slitrk5a zebrafish mutants using CRISPR-Cas9. Alterations in slitrk5a did not affect F 0 gross embryonic development or anxiety-like behaviors, however, a repetitive, checking behavior was significantly increased in the novel approach test (NAT). This observation in zebrafish supports an emerging association of SLITRK5 sequence alterations with OCD-like repetitive behaviors.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping