PUBLICATION
The role of transient receptor potential vanilloid 1 (TRPV1) in Candida albicans infection-induced oral burning sensation: Evidenced from mouse and zebrafish models
- Authors
- Sung, H.M., Choi, E.Y., Joo, J.Y., Park, H.R., Ok, S.M., Oh, C.K.
- ID
- ZDB-PUB-250715-1
- Date
- 2025
- Source
- Journal of dental sciences 20: 148014891480-1489 (Journal)
- Registered Authors
- Keywords
- Candida albicans, Oral burning sensation, Transient receptor potential vanilloid 1(TRPV1), Trigeminal ganglion, Zebrafish
- MeSH Terms
- none
- PubMed
- 40654443 Full text @ J Dent Sci
Citation
Sung, H.M., Choi, E.Y., Joo, J.Y., Park, H.R., Ok, S.M., Oh, C.K. (2025) The role of transient receptor potential vanilloid 1 (TRPV1) in Candida albicans infection-induced oral burning sensation: Evidenced from mouse and zebrafish models. Journal of dental sciences. 20:148014891480-1489.
Abstract
Background/purpose Burning sensation in the oral cavity impairs quality of life, with Candida albicans infection identified as a potential cause due to its inflammatory effects. This study examines the role of the transient receptor potential vanilloid 1 (TRPV1) ion channel in mediating C. albicans-induced burning sensations using clinical data, mouse models, and zebrafish embryos.
Materials and methods Tongue pain intensity in 173 patients was assessed using the Numerical rating scale (NRS, 0-10) before and after nystatin treatment. Mice were infected with C. albicans under immunosuppression, and TRPV1 expression in trigeminal ganglia was analyzed via immunohistochemistry and Quantitative real-time PCR. Zebrafish embryos were microinjected with C. albicans to evaluate trpv1(Zebrafish ortholog) expression using in situ hybridization.
Results Patients with elevated C. albicans CFU levels showed higher NRS scores, which improved following nystatin treatment. Infected mice displayed nerve damage and increased TRPV1 expression in trigeminal ganglia. Zebrafish embryos also showed trpv1 upregulation, confirming infection-induced neuroinflammation.
Conclusion C. albicans infection induces oral burning sensations by increasing TRPV1 expression. Targeting TRPV1 may offer a new therapeutic approach for managing infection-related oral pain.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping