PUBLICATION
Enhanced Antioxidant and Anti-inflammatory Properties of Albino Cordyceps militaris: A Comparative Study With Wild-type Strain
- Authors
- Vu, T.X., Nguyen, M.T., Dao, A.N., Tran, T.B., Le, Y.T.H., Tran, V.T., Nguyen, T.H., Nguyen, Q.V.
- ID
- ZDB-PUB-250628-8
- Date
- 2025
- Source
- Chemistry & biodiversity : e01100e01100 (Journal)
- Registered Authors
- Keywords
- Cordyceps militaris, antioxidant, anti‐inflammatory, cordycepin, pentostatin
- MeSH Terms
-
- Zebrafish
- Animals
- Cattle
- Cordyceps*/chemistry
- Cordyceps*/metabolism
- Antioxidants*/chemistry
- Antioxidants*/isolation & purification
- Antioxidants*/pharmacology
- Serum Albumin, Bovine/antagonists & inhibitors
- Serum Albumin, Bovine/metabolism
- Biphenyl Compounds/antagonists & inhibitors
- Anti-Inflammatory Agents*/chemistry
- Anti-Inflammatory Agents*/isolation & purification
- Anti-Inflammatory Agents*/pharmacology
- Lipopolysaccharides/antagonists & inhibitors
- Lipopolysaccharides/pharmacology
- Picrates/antagonists & inhibitors
- Copper
- Oxidative Stress/drug effects
- PubMed
- 40577383 Full text @ Chem. Biodivers.
Citation
Vu, T.X., Nguyen, M.T., Dao, A.N., Tran, T.B., Le, Y.T.H., Tran, V.T., Nguyen, T.H., Nguyen, Q.V. (2025) Enhanced Antioxidant and Anti-inflammatory Properties of Albino Cordyceps militaris: A Comparative Study With Wild-type Strain. Chemistry & biodiversity. :e01100e01100.
Abstract
Cordyceps militaris is a medicinal fungus known for its immunomodulatory effects. This study compared the antioxidant and anti-inflammatory activities of an albino strain (C. militaris SHBTQ) and its wild-type counterpart (SHQ) using ethanol extracts from their fruiting bodies. The albino strain exhibited significantly higher bioactive compound levels, with cordycepin and pentostatin concentrations 2.37- and 1.74-fold higher than in the wild type. Enhanced polyphenol and flavonoid content correlated with stronger 1,1-diphenyl-2-picrylhydrazyl and azino-bis-(3-ethylbenzothiazoline sulfonate) radical scavenging (2.67- and 1.91-fold higher) and superior copper-chelating ability (97.52% vs. 51.83% at 5 mg/L). It also demonstrated greater anti-inflammatory effects, with a lower 50% inhibitory concentration in the bovine serum albumin denaturation assay (7.42 vs. 14.49 mg/mL) and reduced oxidative stress in zebrafish models. The superior bioactivity of SHBTQ, likely due to its high bioactive compound content, underscores its therapeutic potential against oxidative stress-related diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping