PUBLICATION
A supramolecular system of bioactive ionic liquid, peony extract, and peptide for enhanced permeability and synergistic skincare benefits
- Authors
- Wang, M., Liu, T., Wang, H., Wang, Z., Zhang, J.
- ID
- ZDB-PUB-250617-13
- Date
- 2025
- Source
- Chemistry (Weinheim an der Bergstrasse, Germany) : e202501323e202501323 (Journal)
- Registered Authors
- Keywords
- acetyl hexapeptide-8, bioactive ionic liquid, multiple anti-aging, peony extract, supramolecular
- MeSH Terms
-
- Animals
- Betaine/chemistry
- Humans
- Ionic Liquids*/chemistry
- Malates/chemistry
- Peptides*/chemistry
- Peptides*/pharmacology
- Permeability
- Plant Extracts*/chemistry
- Plant Extracts*/pharmacology
- Reactive Oxygen Species/metabolism
- Skin/drug effects
- Skin/metabolism
- Skin Aging/drug effects
- Zebrafish
- PubMed
- 40522284 Full text @ Chemistry
Citation
Wang, M., Liu, T., Wang, H., Wang, Z., Zhang, J. (2025) A supramolecular system of bioactive ionic liquid, peony extract, and peptide for enhanced permeability and synergistic skincare benefits. Chemistry (Weinheim an der Bergstrasse, Germany). :e202501323e202501323.
Abstract
The growing demand for safe and sustainable cosmetics has led to a marked inclination toward natural extracts and peptides as raw materials. In this study, we developed a sustainable system with multiple anti-aging effects by combining peony extract (PE) and acetyl hexapeptide-8 (AHP8) to simultaneously treat static and dynamic wrinkles, as well as skin dullness. As the poor skin permeability of AHP8 limited its efficacy, we used a bioactive ionic liquid derived from betaine and malic acid ([Bet][MA]) as a permeation enhancer. In vitro and in vivo zebrafish experiments indicated that [Bet][MA] not only significantly enhances transdermal and cellular penetration but also exerts synergistic anti-aging effects. While being biosafe, [Bet][MA] significantly increased the transdermal permeation, skin retention, and cellular uptake of AHP8. Theoretical calculations revealed that [Bet][MA] improved the anti-wrinkle and whitening efficacies of AHP8 and PE through supramolecular interactions; it modulated their electron cloud distribution and molecular polarity and thus intensified their affinity to target proteins in aqueous solutions. The supramolecular PE/AHP8/[Bet][MA] system demonstrated excellent radical- and reactive oxygen species-scavenging capability, collagen production, and tissue repair capability while concurrently inhibiting tyrosinase activity, motion signaling, and inflammation. The study findings pave the way for sustainable and multifunctional skincare solutions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping