PUBLICATION
Zebrafish as a model for olfactory research: A systematic review from molecular mechanism to technology application
- Authors
- Zhu, J., Chen, Y., Liu, X., Sun, Z., Zhang, J., Shen, T., Niu, Y., Xiao, Z.
- ID
- ZDB-PUB-250517-4
- Date
- 2025
- Source
- Food Chemistry 487: 144698144698 (Review)
- Registered Authors
- Keywords
- Applications, Interactions, Odor molecules, Olfactory receptors, Zebrafish
- MeSH Terms
-
- Animals
- Zebrafish*/genetics
- Zebrafish*/physiology
- Models, Animal
- Receptors, Odorant/chemistry
- Receptors, Odorant/genetics
- Receptors, Odorant/metabolism
- Humans
- Smell*
- Odorants/analysis
- PubMed
- 40373719 Full text @ Food Chem.
Citation
Zhu, J., Chen, Y., Liu, X., Sun, Z., Zhang, J., Shen, T., Niu, Y., Xiao, Z. (2025) Zebrafish as a model for olfactory research: A systematic review from molecular mechanism to technology application. Food Chemistry. 487:144698144698.
Abstract
Zebrafish with unique biological traits can serve as an ideal model for studying olfactory mechanisms. This review analyzes their olfactory system, focusing on the regulation of receptor gene expression, mechanisms of odor recognition, and research methodologies including behavioral assays, molecular docking, and biotechnological approaches. Current limitations include predominantly qualitative data, insufficient cross-species comparisons, and unclear mechanisms of environmental modulation. Nevertheless, zebrafish models show significant potential in deciphering human olfaction and applications in neuroscience, biotechnology, healthcare, food safety, and environmental monitoring. Future research should establish cross-species olfactory databases, standardize behavioral assessments, and resolve technical bottlenecks to advance applications in precision medicine, food quality control, and pollutant detection.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping