PUBLICATION
Comprehensive Assessment of Tris(2-ethylhexyl) Trimellitate Acute Toxicity and Ecological Risks: Species-Specific Sensitivity and Environmental Monitoring
- Authors
- Matsuo, Y., Jiang, J.J., Horie, Y.
- ID
- ZDB-PUB-250515-35
- Date
- 2025
- Source
- Environmental pollution (Barking, Essex : 1987) : 126413126413 (Journal)
- Registered Authors
- Keywords
- Japanese medaka, MEC/PNEC ratio, TOTM, ecotoxicity, non-phthalate plasticizer, zebrafish
- MeSH Terms
-
- Animals
- Zebrafish
- Risk Assessment
- Water Pollutants, Chemical*/toxicity
- Oryzias
- Toxicity Tests, Acute
- Plasticizers*/toxicity
- Environmental Monitoring*
- Species Specificity
- PubMed
- 40368011 Full text @ Environ. Pollut.
Citation
Matsuo, Y., Jiang, J.J., Horie, Y. (2025) Comprehensive Assessment of Tris(2-ethylhexyl) Trimellitate Acute Toxicity and Ecological Risks: Species-Specific Sensitivity and Environmental Monitoring. Environmental pollution (Barking, Essex : 1987). :126413126413.
Abstract
Tris(2-ethylhexyl) trimellitate (TOTM), a non-phthalate plasticizer, has gained popularity as a safer alternative to phthalates; however, its ecotoxicological impact and environmental behavior remain unclear. In this study, we investigated the species-specific sensitivity of Oryzias latipes (Japanese medaka) and Danio rerio (zebrafish) to TOTM exposure, and determined the residual concentrations in aquatic environments and ecological risk. Embryonic and larval toxicity tests revealed significant species differences: zebrafish showed higher sensitivity, with a lowest observed effect concentration (LOEC) of 43.7 μg/L, exhibiting increased mortality, swim bladder inflation failure, and growth inhibition. In contrast, the Japanese medaka showed no significant adverse effects under similar exposure conditions. TOTM residues were detected in a single sample (348.2 ng/L) after environmental monitoring of the Sumiyoshi River over 3 months, highlighting potential environmental persistence despite limited detection. Risk assessment using the ratio of the measured environmental concentration (MEC) to the predicted no effect concentration (PNEC) revealed a value > 13, indicating a significant ecological risk posed by the TOTM. These findings underscore the importance of evaluating species-specific responses, conducting comprehensive environmental monitoring, and addressing ecological risks associated with TOTM contamination in aquatic environments.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping