PUBLICATION
The Application of scRNA-Seq in Heart Development and Regeneration
- Authors
- Gao, J., Yu, L., Qi, H., Qi, J., Zheng, Z.
- ID
- ZDB-PUB-250430-7
- Date
- 2025
- Source
- Genesis (New York, N.Y. : 2000) 63: e70013e70013 (Review)
- Registered Authors
- Gao, Junying
- Keywords
- adult heart regeneration, embryonic heart development, neonatal heart regeneration, scRNA‐seq
- MeSH Terms
-
- Heart*/growth & development
- Heart*/physiology
- Zebrafish
- RNA-Seq*/methods
- Sequence Analysis, RNA/methods
- Single-Cell Analysis*/methods
- Single-Cell Gene Expression Analysis
- Regeneration*/genetics
- Animals
- Humans
- PubMed
- 40300044 Full text @ Genesis
Citation
Gao, J., Yu, L., Qi, H., Qi, J., Zheng, Z. (2025) The Application of scRNA-Seq in Heart Development and Regeneration. Genesis (New York, N.Y. : 2000). 63:e70013e70013.
Abstract
Single-cell RNA sequencing (scRNA-seq) is a rapidly developing and useful technique for elucidating biological mechanisms and characterizing individual cells. Tens of millions of patients worldwide suffer from heart injuries and other types of heart disease. Neonatal mammalian hearts and certain adult vertebrate species, such as zebrafish, can fully regenerate after myocardial injury. However, the adult mammalian heart is unable to regenerate the damaged myocardium. scRNA-seq provides many new insights into pathological and normal hearts and facilitates our understanding of cellular responses to cardiac injury and repair at different stages, which may provide critical clues for effective therapies for adult heart regeneration. In this review, we summarize the application of scRNA-seq in heart development and regeneration and describe how important molecular mechanisms can be harnessed to promote heart regeneration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping