PUBLICATION
Social context prevents heat hormetic effects against mutagens during fish development
- Authors
- Feugere, L., Silva De Freitas, C., Bates, A., Storey, K.B., Beltran-Alvarez, P., Wollenberg Valero, K.C.
- ID
- ZDB-PUB-250424-2
- Date
- 2025
- Source
- FEBS letters : (Journal)
- Registered Authors
- Keywords
- DNA repair, UV damage, carryover effect, heat stress, hormetic effect, stress communication
- MeSH Terms
- none
- PubMed
- 40265659 Full text @ FEBS Lett.
Citation
Feugere, L., Silva De Freitas, C., Bates, A., Storey, K.B., Beltran-Alvarez, P., Wollenberg Valero, K.C. (2025) Social context prevents heat hormetic effects against mutagens during fish development. FEBS letters. :. Epub ahead of print.
Abstract
Since stress can be transmitted to congeners via social metabolites, it is paramount to understand how the social context of abiotic stress influences aquatic organisms' responses to global changes. Here, we integrated the transcriptomic and phenotypic responses of zebrafish embryos to a UV damage/repair assay following scenarios of heat stress, its social context and their combination. Heat stress preceding UV exposure had a hormetic effect through the cellular stress response and DNA repair, rescuing and/or protecting embryos from UV damage. However, experiencing heat stress within a social context negated this molecular hormetic effect and lowered larval fitness. We discuss the molecular basis of interindividual chemical transmission within animal groups as another layer of complexity to organisms' responses to environmental stressors.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping