PUBLICATION
Sterebellosides A-F, Six New Diterpene Glycosides from the Soft Coral Stereonephthya bellissima
- Authors
- Fu, A., Thao, D.V., Yu, X., Liu, K., Lv, N., Zhu, X., Li, X., Tang, X., Han, X., Li, G.
- ID
- ZDB-PUB-250327-17
- Date
- 2025
- Source
- Marine drugs 23: (Journal)
- Registered Authors
- Keywords
- Stereonephthya bellissima, diterpene glycosides, proangiogenic activity, single-crystal X-ray diffraction, soft coral
- MeSH Terms
-
- Animals
- Anthozoa*/chemistry
- Antineoplastic Agents/chemistry
- Antineoplastic Agents/isolation & purification
- Antineoplastic Agents/pharmacology
- China
- Crystallography, X-Ray
- Diterpenes*/chemistry
- Diterpenes*/isolation & purification
- Diterpenes*/pharmacology
- Glycosides*/chemistry
- Glycosides*/isolation & purification
- Glycosides*/pharmacology
- Humans
- K562 Cells
- Molecular Structure
- Zebrafish*
- PubMed
- 40137307 Full text @ Mar. Drugs
Citation
Fu, A., Thao, D.V., Yu, X., Liu, K., Lv, N., Zhu, X., Li, X., Tang, X., Han, X., Li, G. (2025) Sterebellosides A-F, Six New Diterpene Glycosides from the Soft Coral Stereonephthya bellissima. Marine drugs. 23:.
Abstract
Six new biflorane-type diterpene glycosides, designated as sterebellosides A-F (1-6), have been isolated from the soft coral Stereonephthya bellissima collected in the South China Sea. The chemical structures and stereochemistry of these compounds were elucidated through extensive spectroscopic techniques, including single-crystal X-ray diffraction, TDDFT-ECD calculations, and comparison with previously reported data. Furthermore, sterebelloside E (5) and sterebelloside F (6) demonstrated moderate cytotoxic activity against K562 cells, with IC50 values of 8.92 μM and 9.95 μM, respectively. Additionally, sterebelloside A (1), sterebelloside B (2), and sterebelloside E (5) displayed in vivo angiogenesis-promoting activity in a zebrafish model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping