PUBLICATION
Metabolomics study reveals DON-induced intestinal toxicity in adult zebrafish through disruption of amino acid metabolism and sphingolipid signaling pathway
- Authors
- Wang, Y., Wang, L., Du, Y., Yao, F., Zhao, M., Cai, C., Zhu, R., Shao, S.
- ID
- ZDB-PUB-250321-6
- Date
- 2025
- Source
- Aquatic toxicology (Amsterdam, Netherlands) 282: 107324107324 (Journal)
- Registered Authors
- Keywords
- Deoxynivalenol, Differential metabolites, Intestinal metabolome, Toxic effects, Zebrafish
- MeSH Terms
-
- Amino Acids*/metabolism
- Animals
- Intestines*/drug effects
- Metabolome/drug effects
- Metabolomics
- Signal Transduction/drug effects
- Sphingolipids*/metabolism
- Trichothecenes*/toxicity
- Water Pollutants, Chemical*/toxicity
- Zebrafish*/metabolism
- PubMed
- 40112585 Full text @ Aquat. Toxicol.
Citation
Wang, Y., Wang, L., Du, Y., Yao, F., Zhao, M., Cai, C., Zhu, R., Shao, S. (2025) Metabolomics study reveals DON-induced intestinal toxicity in adult zebrafish through disruption of amino acid metabolism and sphingolipid signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). 282:107324107324.
Abstract
Deoxynivalenol (DON), a prevalent mycotoxin contaminating cereal crops globally, poses significant threats to animal and human health through its gastrointestinal toxicity. While DON-induced intestinal damage has been documented in mammals, its metabolic mechanisms in aquatic species remain poorly understood, particularly in adult zebrafish models that offer unique advantages for toxicological studies. Multi-omics analysis revealed 16 key differential metabolites (9 upregulated, 7 downregulated) associated with amino acid metabolism and carbohydrate homeostasis. Pathway enrichment analysis identified significant perturbations in 2-oxocarboxylic acid metabolism and sphingolipid signaling, suggesting mitochondrial dysfunction and epithelial barrier disruption as primary toxicity mechanisms. This study establishes the first adult zebrafish model for DON intestinal toxicity evaluation, demonstrating its utility in revealing conserved metabolic targets across species. The identified pathway-specific biomarkers provide novel insights for developing dietary interventions against mycotoxin exposure.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping