PUBLICATION
BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation
- Authors
- Tavano, S., Brückner, D.B., Tasciyan, S., Tong, X., Kardos, R., Schauer, A., Hauschild, R., Heisenberg, C.P.
- ID
- ZDB-PUB-250310-19
- Date
- 2025
- Source
- Cell Reports 44: 115387115387 (Journal)
- Registered Authors
- Heisenberg, Carl-Philipp
- Keywords
- BMP signaling, CP: Developmental biology, ECM-independent cell migration, cell migration, cell migration on cellular substrates, ectoderm, gastrulation, lateral mesendoderm, tissue material properties, zebrafish
- Datasets
- GEO:GSE251904
- MeSH Terms
-
- Zebrafish Proteins*/genetics
- Zebrafish Proteins*/metabolism
- Animals
- Cell Movement*
- Gastrula/metabolism
- Gene Expression Regulation, Developmental
- Mesoderm*/cytology
- Mesoderm*/metabolism
- Zebrafish*/embryology
- Zebrafish*/metabolism
- Ectoderm*/cytology
- Ectoderm*/metabolism
- Bone Morphogenetic Proteins*/metabolism
- Gastrulation*
- Signal Transduction
- Body Patterning
- PubMed
- 40057955 Full text @ Cell Rep.
Citation
Tavano, S., Brückner, D.B., Tasciyan, S., Tong, X., Kardos, R., Schauer, A., Hauschild, R., Heisenberg, C.P. (2025) BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation. Cell Reports. 44:115387115387.
Abstract
Cell migration is a fundamental process during embryonic development. Most studies in vivo have focused on the migration of cells using the extracellular matrix (ECM) as their substrate for migration. In contrast, much less is known about how cells migrate on other cells, as found in early embryos when the ECM has not yet formed. Here, we show that lateral mesendoderm (LME) cells in the early zebrafish gastrula use the ectoderm as their substrate for migration. We show that the lateral ectoderm is permissive for the animal-pole-directed migration of LME cells, while the ectoderm at the animal pole halts it. These differences in permissiveness depend on the lateral ectoderm being more cohesive than the animal ectoderm, a property controlled by bone morphogenetic protein (BMP) signaling within the ectoderm. Collectively, these findings identify ectoderm tissue cohesion as one critical factor in regulating LME migration during zebrafish gastrulation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping