PUBLICATION
Study on the Hepatotoxicity of Emodin and Its Application in the Treatment of Liver Fibrosis
- Authors
- Guo, Y., Song, J., Liu, Y., Yuan, M., Zhong, W., Guo, Y., Guo, L.
- ID
- ZDB-PUB-241114-7
- Date
- 2024
- Source
- Molecules 29(21): (Journal)
- Registered Authors
- Keywords
- co-delivery system, emodin, liver fibrosis, tetrandrine, toxicity
- MeSH Terms
-
- Emodin*/pharmacology
- Emodin*/therapeutic use
- Transforming Growth Factor beta/metabolism
- Benzylisoquinolines
- Zebrafish*
- Liposomes
- Liver Cirrhosis*/drug therapy
- Liver Cirrhosis*/pathology
- Animals
- Interleukin-1beta/metabolism
- Mice
- Liver/drug effects
- Liver/metabolism
- Liver/pathology
- Male
- Nanoparticles*/chemistry
- PubMed
- 39519763 Full text @ Molecules
Citation
Guo, Y., Song, J., Liu, Y., Yuan, M., Zhong, W., Guo, Y., Guo, L. (2024) Study on the Hepatotoxicity of Emodin and Its Application in the Treatment of Liver Fibrosis. Molecules. 29(21):.
Abstract
Emodin (EMO) is an anthraquinone compound derived from Rheum palmatum L., which has rich pharmacological activity. However, studies have shown that EMO may cause hepatotoxicity. In this study, EMO was combined with tetrandrine and prepared as lipid nanoparticles (E-T/LNPs). The anti-liver fibrosis activity of EMO before and after formulation was evaluated by zebrafish and mice. In addition, the toxicity of EMO and E-T/LNPs was compared and the toxicity-efficacy concentrations of E-T/LNPs in zebrafish were verified. E-T/LNPs are morphologically stable (particle size within 100 nm), have high encapsulation efficiency and good stability, and are capable of long-lasting slow release in vitro. The combination and preparation can reduce the toxicity and enhance the effect of EMO, and increase the toxicity and effect concentration of E-T/LNPs in vivo. In a short period, low doses of E-T/LNPs can be used for the treatment of liver fibrosis; high doses of E-T/LNPs cause toxicity in vivo. Immunohistochemistry showed that E-T/LNPs inhibited hepatic fibrosis by downregulating the levels of IL-1β and TGF-β. Based on the advantages of combination therapy and nanotechnology, it can play a role in reducing the toxicity and increasing the efficacy of EMO in the treatment of liver fibrosis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping