PUBLICATION
Talauromides A-G, Nitrogen-Containing Heptacyclic Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus BMC-16
- Authors
- Zong, S., Zhang, Y., Xiao, J., Cong, Y., Bi, Z., Sun, C., Wang, H., Wei, Y., Rong, X., Zhou, J., Li, D., Zhu, M.
- ID
- ZDB-PUB-241018-3
- Date
- 2024
- Source
- Journal of natural products 87(10): 2450-2458 (Journal)
- Registered Authors
- Rong, Xiaozhi, Zhou, Jianfeng
- Keywords
- none
- MeSH Terms
-
- Molecular Structure
- Wnt Signaling Pathway/drug effects
- Talaromyces*/chemistry
- Soil Microbiology
- Phenalenes*/chemistry
- Phenalenes*/isolation & purification
- Phenalenes*/pharmacology
- Animals
- Zebrafish*
- Nitrogen/chemistry
- PubMed
- 39412829 Full text @ J. Nat. Prod.
Citation
Zong, S., Zhang, Y., Xiao, J., Cong, Y., Bi, Z., Sun, C., Wang, H., Wei, Y., Rong, X., Zhou, J., Li, D., Zhu, M. (2024) Talauromides A-G, Nitrogen-Containing Heptacyclic Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus BMC-16. Journal of natural products. 87(10):2450-2458.
Abstract
Seven new nitrogen-containing heptacyclic oligophenalenone dimers, talauromides A-G (1-7), together with known compounds bacillisporins A and B (8 and 9), talaromycesones C and B (10 and 11), duclauxin (12) and lamellicolic anhydride (13), were isolated from the soil derived-fungus Talaromyces stipitatus BMC-16. Their chemical structures were determined based on spectroscopic analysis data. The absolute configurations were elucidated by chemical approaches and the comparison of CD spectra with related compounds. Compounds 3, 8 and 11 exhibited inhibitory activity on the Wnt/β-catenin signaling pathway in zebrafish embryos at a concentration of 20 μM.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping