PUBLICATION
Fin elaboration via anterior-posterior constraint by hhip on Hedgehog signaling in teleosts
- Authors
- Tanaka, Y., Okayama, S., Urakawa, K., Kudoh, H., Ansai, S., Abe, G., Tamura, K.
- ID
- ZDB-PUB-241018-16
- Date
- 2024
- Source
- Development (Cambridge, England) 151(22): (Journal)
- Registered Authors
- Abe, Gembu
- Keywords
- Evo-devo, Fin development, Hhip, Shh, Teleost
- MeSH Terms
-
- Zebrafish Proteins*/genetics
- Zebrafish Proteins*/metabolism
- Signal Transduction*
- Animal Fins*/embryology
- Animal Fins*/metabolism
- Hedgehog Proteins*/genetics
- Hedgehog Proteins*/metabolism
- Animals
- Zebrafish*/genetics
- Gene Expression Regulation, Developmental*
- Mutation/genetics
- PubMed
- 39417578 Full text @ Development
Citation
Tanaka, Y., Okayama, S., Urakawa, K., Kudoh, H., Ansai, S., Abe, G., Tamura, K. (2024) Fin elaboration via anterior-posterior constraint by hhip on Hedgehog signaling in teleosts. Development (Cambridge, England). 151(22):.
Abstract
Pectoral fins, the anterior paired fins in fish, have enhanced maneuvering abilities due to morphological changes. Teleosts have fewer radial bones in their pectoral fins than basal species, resulting in more elaborate fins. The mechanism behind this radial constraint change in teleosts is unclear. Here, we found that mutations in hhip, an antagonist of Hedgehog signaling, lead to an increase in radial bones in a localized region. The shh genes, ligands of Hedgehog signaling, were expressed coinciding with notable hhip expression specifically during early development. We suggest that a negative feedback effect of Hedgehog signaling by hhip regulates the constraint of the pectoral fin in zebrafish. Additionally, the expression reanalysis of Hhip-related genes implied that the notable hhip expression during early development was a characteristic of zebrafish, not observed in basal species. Region-specific expression of Hox13 genes indicated that hhip-/- zebrafish expanded the median region of the pectoral fin, analogous to the region with abundant radials in basal species. The data underscore potential morphological evolution through constrained diversity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping