PUBLICATION
Oscillatory DeltaC Expression in Neural Progenitors Primes the Prototype of Forebrain Development
- Authors
- Nian, F.S., Liao, B.K., Su, Y.L., Wu, P.R., Tsai, J.W., Hou, P.S.
- ID
- ZDB-PUB-241012-3
- Date
- 2024
- Source
- Molecular neurobiology : (Journal)
- Registered Authors
- Keywords
- Delta gene, Forebrain development, Notch signaling, Oscillation pattern
- MeSH Terms
-
- Membrane Proteins/genetics
- Membrane Proteins/metabolism
- Zebrafish*/genetics
- Zebrafish*/metabolism
- Neural Stem Cells*/metabolism
- Animals
- Prosencephalon*/embryology
- Prosencephalon*/metabolism
- Signal Transduction
- Receptors, Notch*/metabolism
- Zebrafish Proteins*/genetics
- Zebrafish Proteins*/metabolism
- Cell Differentiation
- Neurogenesis*
- Gene Expression Regulation, Developmental*
- PubMed
- 39392541 Full text @ Mol. Neurobiol.
Citation
Nian, F.S., Liao, B.K., Su, Y.L., Wu, P.R., Tsai, J.W., Hou, P.S. (2024) Oscillatory DeltaC Expression in Neural Progenitors Primes the Prototype of Forebrain Development. Molecular neurobiology. :.
Abstract
Notch signaling plays a pivotal role in regulating various developmental processes, particularly in controlling the timing of neuronal production within the developing neocortex. Central to this regulatory mechanism is the oscillatory pattern of Delta, which functions as a developmental clock modulator. Its deficiency profoundly impairs mammalian brain formation, highlighting its fundamental role in brain development. However, zebrafish carrying a mutation in the functional ortholog DeltaC (dlc) within their functional ortholog exhibit an intact forebrain structure, implying evolutionary variations in Notch signaling within the forebrain. In this study, we unveil the distinct yet analogous expression profiles of Delta and Her genes in the developing vertebrate forebrain. Specifically, for the first time, we detected the oscillatory expression of the Delta gene dlc in the developing zebrafish forebrain. Although this oscillatory pattern appeared irregular and was not pervasive among the progenitor population, attenuation of the dlc-involved Notch pathway using a γ-secretase inhibitor impaired neuronal differentiation in the developing zebrafish forebrain, revealing the indispensable role of the dlc-involved Notch pathway in regulating early zebrafish neurogenesis. Taken together, our results demonstrate the foundational prototype of dlc-involved Notch signaling in the developing zebrafish forebrains, upon which the intricate patterns of the mammalian neocortex may have been sculpted.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping