PUBLICATION
Adult zebrafish can learn Morris water maze-like tasks in a two-dimensional virtual reality system
- Authors
- Islam, T., Torigoe, M., Tanimoto, Y., Okamoto, H.
- ID
- ZDB-PUB-240925-9
- Date
- 2024
- Source
- Cell reports methods 4(10): 100863 (Journal)
- Registered Authors
- Islam, Tanvir, Okamoto, Hitoshi, Tanimoto, Yuki
- Keywords
- CP: Biotechnology, CP: Neuroscience, LabVIEW, MATLAB, Morris water maze, Unity engine, goal-headedness, navigation, persistence, spatial learning, virtual reality, zebrafish
- MeSH Terms
-
- Animals
- Maze Learning/physiology
- Morris Water Maze Test
- Spatial Navigation/physiology
- Virtual Reality*
- Zebrafish*/physiology
- PubMed
- 39317191 Full text @ Cell Rep Methods
Citation
Islam, T., Torigoe, M., Tanimoto, Y., Okamoto, H. (2024) Adult zebrafish can learn Morris water maze-like tasks in a two-dimensional virtual reality system. Cell reports methods. 4(10):100863.
Abstract
Virtual reality (VR) has emerged as a powerful tool for investigating neural mechanisms of decision-making, spatial cognition, and navigation. In many head-fixed VRs for rodents, animals locomote on spherical treadmills that provide rotation information in two axes to calculate two-dimensional (2D) movement. On the other hand, zebrafish in a submerged head-fixed VR can move their tail to enable movement in 2D VR environment. This motivated us to create a VR system for adult zebrafish to enable 2D movement consisting of forward translation and rotations calculated from tail movement. Besides presenting the VR system, we show that zebrafish can learn a virtual Morris water maze-like (VMWM) task in which finding an invisible safe zone was necessary for the zebrafish to avoid an aversive periodic mild electric shock. Results show high potential for our VR system to be combined with optical imaging for future studies to investigate spatial learning and navigation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping