PUBLICATION
Fucoxanthin Attenuates Angiogenesis by Blocking the VEGFR2-Mediated Signaling Pathway through Binding the Vascular Endothelial Growth Factor
- Authors
- Guo, G.X., Qiu, Y.H., Liu, Y., Yu, L.L., Zhang, X., Tsim, K.W., Qin, Q.W., Hu, W.H.
- ID
- ZDB-PUB-240919-2
- Date
- 2024
- Source
- Journal of Agricultural and Food Chemistry 72(39): 21610-21623 (Journal)
- Registered Authors
- Keywords
- VEGF, VEGFR2, angiogenesis, fucoxanthin, natural compound
- MeSH Terms
-
- Angiogenesis Inhibitors/chemistry
- Angiogenesis Inhibitors/pharmacology
- Humans
- Vascular Endothelial Growth Factor A*/genetics
- Vascular Endothelial Growth Factor A*/metabolism
- Phaeophyceae/chemistry
- Animals
- Signal Transduction*/drug effects
- Neovascularization, Pathologic/drug therapy
- Neovascularization, Pathologic/metabolism
- Human Umbilical Vein Endothelial Cells*/drug effects
- Human Umbilical Vein Endothelial Cells*/metabolism
- Cell Movement*/drug effects
- Vascular Endothelial Growth Factor Receptor-2*/genetics
- Vascular Endothelial Growth Factor Receptor-2*/metabolism
- Cell Proliferation*/drug effects
- Zebrafish*
- Xanthophylls*/chemistry
- Xanthophylls*/pharmacology
- Angiogenesis
- PubMed
- 39292861 Full text @ J. Agric. Food Chem.
Citation
Guo, G.X., Qiu, Y.H., Liu, Y., Yu, L.L., Zhang, X., Tsim, K.W., Qin, Q.W., Hu, W.H. (2024) Fucoxanthin Attenuates Angiogenesis by Blocking the VEGFR2-Mediated Signaling Pathway through Binding the Vascular Endothelial Growth Factor. Journal of Agricultural and Food Chemistry. 72(39):21610-21623.
Abstract
Fucoxanthin, a dietary carotenoid, is predominantly found in edible brown algae and is commonly consumed worldwide. Fucoxanthin has been shown to possess beneficial health activities such as antidiabetic, anti-inflammatory, antimutagenic, and antiobesity; however, the effects of fucoxanthin on VEGF-mediated angiogenesis and its possible binding with VEGF are unknown. Here, different lines of evidence supported the suppressive roles of fucoxanthin in VEGF-mediated angiogenesis. In human umbilical vein endothelial cells, fucoxanthin remarkedly suppressed VEGF-mediated cell proliferative, migration, and invasive abilities, as well as tube formation, without cytotoxicity. In addition, fucoxanthin inhibited the subintestinal vessel formation of zebrafish in vivo. In signaling cascades, fucoxanthin was proposed to interact with VEGF, thus attenuating VEGF's functions in activating the VEGF receptor and its related downstream signaling, i.e., phosphorylations of MEK and Erk. Fucoxanthin also significantly blocked VEGF-triggered ROS formation. Furthermore, the outcomes of applying fucoxanthin in cancer cells were identified, which included (i) inhibiting VEGF-mediated cell proliferation and migration and (ii) inhibiting NF-κB translocation via limiting MMP2 expression. These lines of investigations supported the antiangiogenic roles of fucoxanthin, as well as reviewing its signaling mechanisms, in blocking the VEGF-triggered responses. The results would benefit the potential development of fucoxanthin for the prevention and treatment of angiogenesis-related diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping