PUBLICATION
Gluconeogenesis in the yolk syncytial layer-like tissue of cloudy catshark (Scyliorhinus torazame)
- Authors
- Shimizu, M., Takagi, W., Sakai, Y., Kayanuma, I., Furukawa, F.
- ID
- ZDB-PUB-240530-10
- Date
- 2024
- Source
- Physiological Reports 12: e16088e16088 (Journal)
- Registered Authors
- Keywords
- Torazame catshark, glucose, shark, vertebrate, yolk syncytial layer
- MeSH Terms
-
- Embryo, Nonmammalian
- Gluconeogenesis*
- Yolk Sac/metabolism
- Sharks/metabolism
- Glucose/metabolism
- Animals
- Egg Yolk
- PubMed
- 38811349 Full text @ Physiol. Rep.
Citation
Shimizu, M., Takagi, W., Sakai, Y., Kayanuma, I., Furukawa, F. (2024) Gluconeogenesis in the yolk syncytial layer-like tissue of cloudy catshark (Scyliorhinus torazame). Physiological Reports. 12:e16088e16088.
Abstract
Glucose has important roles in the development of zebrafish, the vertebrate animal model; however, in most oviparous animals, the amount of maternally provided glucose in the yolk is scarce. For these reasons, developing animals need some ways to supplement glucose. Recently, it was found that developing zebrafish, a teleost fish, undergo gluconeogenesis in the yolk syncytial layer (YSL), an extraembryonic tissue that surrounds the yolk. However, teleost YSL is evolutionarily unique, and it is not clear how other vertebrates supplement glucose. In this study, we used cloudy catshark (or Torazame catshark), an elasmobranch species which possesses a YSL-like tissue during development, and sought for possible gluconeogenic activities in this tissue. In their yolk sac, glucose increased, and our isotope tracking analysis detected gluconeogenic activities with glycerol most preferred substrate. In addition, many of gluconeogenic genes were expressed at the YSL-like tissue, suggesting that cloudy catshark engages in gluconeogenesis in this tissue. The gluconeogenesis in teleost YSL and a similar tissue in elasmobranch species implies conserved mechanisms of yolk metabolism between these two lineages. Future studies on other vertebrate taxa will be helpful to understand the evolutionary changes in the modes of yolk metabolism that vertebrates have experienced.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping