PUBLICATION
Comparative Study of the Effects of Different Surface-Coated Silver Nanoparticles on Thyroid Disruption and Bioaccumulation in Zebrafish Early Life
- Authors
- Cao, H., Guo, Y., Ma, C., Wang, Y., Jing, Y., Chen, X., Liang, H.
- ID
- ZDB-PUB-240527-4
- Date
- 2024
- Source
- Chemosphere 360: 142422 (Journal)
- Registered Authors
- Keywords
- AgNPs, Bioaccumulation, HPT axis, Proteins, Thyroid hormone
- MeSH Terms
-
- Silver*/chemistry
- Silver*/toxicity
- Thyroglobulin/metabolism
- Bioaccumulation
- Zebrafish*
- Water Pollutants, Chemical*/toxicity
- Metal Nanoparticles*/chemistry
- Metal Nanoparticles*/toxicity
- Thyroid Gland*/drug effects
- Thyroid Gland*/metabolism
- Animals
- PubMed
- 38795916 Full text @ Chemosphere
Citation
Cao, H., Guo, Y., Ma, C., Wang, Y., Jing, Y., Chen, X., Liang, H. (2024) Comparative Study of the Effects of Different Surface-Coated Silver Nanoparticles on Thyroid Disruption and Bioaccumulation in Zebrafish Early Life. Chemosphere. 360:142422.
Abstract
The widespread use of silver nanoparticles (AgNPs) in commercial and industrial applications has led to their increased presence in the environment, raising concerns about their ecological and health impacts. This study pioneers an investigation into the chronic versus short-term acute toxicological impacts of differently coated AgNPs on zebrafish, with a novel focus on the thyroid-disrupting effects previously unexplored. The results showed that acute toxicity ranked from highest to lowest as AgNO3 (0.128 mg/L), PVP-AgNPs (1.294 mg/L), Citrate-AgNPs (6.984 mg/L), Uncoated-AgNPs (8.269 mg/L). For bioaccumulation, initial peaks were observed at 2 days, followed by fluctuations over time, with the eventual highest enrichment seen in Uncoated-AgNPs and Citrate-AgNPs at concentrations of 13 and 130 μg/L. Additionally, the four exposure groups showed a significant increase in T3 levels, which was 1.28-2.11 times higher than controls, and significant changes in thyroid peroxidase (TPO) and thyroglobulin (TG) content, indicating thyroid disruption. Gene expression analysis revealed distinct changes in the HPT axis-related genes, providing potential mechanisms underlying the thyroid toxicity induced by different AgNPs. The higher the Ag concentration in zebrafish, the stronger the thyroid disrupting effects, which in turn affected growth and development, in the order of Citrate-AgNPs, Uncoated-AgNPs > AgNO3, PVP-AgNPs. This research underscores the importance of considering nanoparticle coatings in risk assessments and offers insights into the mechanisms by which AgNPs affect aquatic organisms' endocrine systems, highlighting the need for careful nanotechnology use and the relevance of these findings for understanding environmental pollutants' role in thyroid disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping