PUBLICATION
EpCAM regulates hair cell development and regeneration in the zebrafish lateral line
- Authors
- Bufalo, A.J., Vanderbeck, M.M., Schmitt, J., McGraw, H.F.
- ID
- ZDB-PUB-240527-19
- Date
- 2024
- Source
- microPublication. Biology 2024: (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 38800699 Full text @ MicroPubl Biol
Citation
Bufalo, A.J., Vanderbeck, M.M., Schmitt, J., McGraw, H.F. (2024) EpCAM regulates hair cell development and regeneration in the zebrafish lateral line. microPublication. Biology. 2024:.
Abstract
The zebrafish lateral line mechanosensory system shares considerable morphological and molecular similarities with the inner ear. In particular, mechanosensory hair cells are responsible for transducing sensory stimuli in both structures. The epithelia cell adhesion molecule (EpCAM) is expressed in the cells of the inner ear of mammals and in the lateral lines system of fish. EpCAM regulates the many cellular functions including adhesion, migration, proliferation, and differentiation. In this study, we use the epcam jh79 mutant zebrafish line to determine that EpCAM function is required for proper development and regeneration of posterior lateral line hair cells.
Genes / Markers
Figure Gallery (1 images)
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping