PUBLICATION
Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps
- Authors
- Phelps, D.W., Connors, A.M., Ferrero, G., DeWitt, J.C., Yoder, J.A.
- ID
- ZDB-PUB-240508-2
- Date
- 2024
- Source
- Journal of immunotoxicology 21: 23433622343362 (Review)
- Registered Authors
- Yoder, Jeffrey A.
- Keywords
- PFAS, Per- and polyfluoroalkyl substances, ecotoxicology, immunotoxicology, innate immunity, zebrafish
- MeSH Terms
-
- Animals
- Environmental Exposure/adverse effects
- Environmental Pollutants*/adverse effects
- Environmental Pollutants*/toxicity
- Fluorocarbons*/adverse effects
- Fluorocarbons*/toxicity
- Humans
- Immunity, Innate*/drug effects
- PubMed
- 38712868 Full text @ J Immunotoxicol
Citation
Phelps, D.W., Connors, A.M., Ferrero, G., DeWitt, J.C., Yoder, J.A. (2024) Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps. Journal of immunotoxicology. 21:23433622343362.
Abstract
Per- and polyfluoroalkyl substances (PFASs) are a large class of compounds used in a variety of processes and consumer products. Their unique chemical properties make them ubiquitous and persistent environmental contaminants while also making them economically viable and socially convenient. To date, several reviews have been published to synthesize information regarding the immunotoxic effects of PFASs on the adaptive immune system. However, these reviews often do not include data on the impact of these compounds on innate immunity. Here, current literature is reviewed to identify and incorporate data regarding the effects of PFASs on innate immunity in humans, experimental models, and wildlife. Known mechanisms by which PFASs modulate innate immune function are also reviewed, including disruption of cell signaling, metabolism, and tissue-level effects. For PFASs where innate immune data are available, results are equivocal, raising additional questions about common mechanisms or pathways of toxicity, but highlighting that the innate immune system within several species can be perturbed by exposure to PFASs. Recommendations are provided for future research to inform hazard identification, risk assessment, and risk management practices for PFASs to protect the immune systems of exposed organisms as well as environmental health.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping