PUBLICATION
Developmental dopaminergic signaling modulates neural circuit formation and contributes to autism spectrum disorder (ASD)-related phenotypes
- Authors
- Lu, X., Song, Y., Wang, J., Cai, Y., Peng, S., Lin, J., Lai, B., Sun, J., Liu, T., Chen, G., Xing, L.
- ID
- ZDB-PUB-240317-9
- Date
- 2024
- Source
- The American journal of pathology 194(6): 1062-1077 (Journal)
- Registered Authors
- Keywords
- autism spectrum disorder (ASD), dopaminergic signaling, integrins, neuron specification, zebrafish
- MeSH Terms
-
- Animals
- Autism Spectrum Disorder*/genetics
- Autism Spectrum Disorder*/metabolism
- Autism Spectrum Disorder*/pathology
- Brain/metabolism
- Brain/pathology
- Disease Models, Animal
- Dopamine*/metabolism
- Dopaminergic Neurons/metabolism
- Dopaminergic Neurons/pathology
- Female
- Humans
- Male
- Neural Pathways/metabolism
- Phenotype*
- Signal Transduction*
- Zebrafish*
- PubMed
- 38492733 Full text @ Am. J. Pathol.
Citation
Lu, X., Song, Y., Wang, J., Cai, Y., Peng, S., Lin, J., Lai, B., Sun, J., Liu, T., Chen, G., Xing, L. (2024) Developmental dopaminergic signaling modulates neural circuit formation and contributes to autism spectrum disorder (ASD)-related phenotypes. The American journal of pathology. 194(6):1062-1077.
Abstract
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder with a complex etiology. Recent evidence suggests that dopamine plays a crucial role in neural development. However, it remains unclear whether and how disrupted dopaminergic signaling during development contributes to ASD. In this study, human brain RNA-seq transcriptome analysis revealed a significant correlation between changes in dopaminergic signaling pathways and neural developmental signaling in ASD patients. In the zebrafish model, disrupted developmental dopaminergic signaling led to neural circuit abnormalities and behavior reminiscent of autism. Dopaminergic signaling may impact neuronal specification by potentially modulating integrins. These findings shed light on the mechanisms underlying the link between disrupted developmental dopamine signaling and ASD, and they point to the possibility of targeting dopaminergic signaling in early development for ASD treatment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping