PUBLICATION
Transgenerational effects of extracts containing Microcystin-LR exposure on reproductive toxicity and offspring growth inhibition in a model organism zebrafish
- Authors
- Yang, Q., Huang, L., Yang, N., Cui, H., Zhao, Y., Li, Z., Tong, Y.
- ID
- ZDB-PUB-240215-5
- Date
- 2024
- Source
- Aquatic toxicology (Amsterdam, Netherlands) 268: 106860106860 (Journal)
- Registered Authors
- Keywords
- Microcystin-LR, Reproductive toxicity, Toxic cyanobacteria, Transgenerational effects, Zebrafish
- MeSH Terms
-
- Humans
- Male
- Female
- Microcystins/toxicity
- Cyanobacteria Toxins
- Zebrafish*/physiology
- Ecosystem
- Antioxidants
- Marine Toxins*
- Water Pollutants, Chemical*/toxicity
- Animals
- PubMed
- 38354462 Full text @ Aquat. Toxicol.
Citation
Yang, Q., Huang, L., Yang, N., Cui, H., Zhao, Y., Li, Z., Tong, Y. (2024) Transgenerational effects of extracts containing Microcystin-LR exposure on reproductive toxicity and offspring growth inhibition in a model organism zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 268:106860106860.
Abstract
Cyanobacteria cell lysates release numerous toxic substances (e.g., cyanotoxins) into the water, posing a serious threat to human health and aquatic ecosystems. Microcystins (MCs) are among the most abundant cyanotoxins in the cell lysates, with microcystin-LR (MC-LR) being one of the most common and highly toxic congeners. In this study, zebrafish (Danio rerio) were exposed to different levels MC-LR that from extracts of Microcystis aeruginosa. Changes in the MC-LR accumulations, organ coefficients, and antioxidant enzyme activities in the zebrafish were analyzed. Transgenerational reproductive toxicity of MC-LR in the maternal and paternal generations was further investigated, as well as the influences of extracts containing MC-LR exposures of the F1 on the growth of zebrafish. The study found that high levels of MC-LR could be detected in the major organs of adult zebrafish, particularly in spleen. Notably, concentration of MC-LR in the spermary was significantly higher than that in the ovarium. MC-LR could induce oxidative damage by affecting the activities of catalase and superoxide dismutase. Inherited from F0, MC-LR led to impaired development in the F1 generation. Difference in offspring survival rates could be observed in the groups with different MC-LR levels of maternal and paternal exposures. This study reveals transgenerational effects of MC-LR on the reproductive toxicity and offspring growth inhibition to the aquatic organisms, which should be emphasized in the future ecological risk assessment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping