PUBLICATION
Hair Cell Regeneration: From Animals to Humans
- Authors
- Choi, S.W., Abitbol, J., Cheng, A.
- ID
- ZDB-PUB-240126-7
- Date
- 2024
- Source
- Clinical and experimental otorhinolaryngology 17(1): 1-14 (Journal)
- Registered Authors
- Keywords
- Cochlea, Hair cells, Hearing loss, Regeneration, supporting cells
- MeSH Terms
- none
- PubMed
- 38271988 Full text @ Clin. Exp. Otorhinolaryngol.
Citation
Choi, S.W., Abitbol, J., Cheng, A. (2024) Hair Cell Regeneration: From Animals to Humans. Clinical and experimental otorhinolaryngology. 17(1):1-14.
Abstract
Cochlear hair cells are critical in converting sound into electrical signals that are relayed via the spiral ganglion neurons to the central auditory pathway. Hair cells are vulnerable to damage caused by excessive noise, aging, and ototoxic agents. Non-mammals can regenerate lost hair cells by mitotic regeneration and direct transdifferentiation of surrounding supporting cells. However, in mature mammals, damaged hair cells are not replaced, resulting in permanent hearing loss. Recent studies have uncovered mechanisms by which sensory organs in non-mammals and the neonatal mammalian cochlea regenerate hair cells, and outlined possible mechanisms why this ability declines rapidly with age in mammals. Here, we review similarities and differences between avian, zebrafish and mammalian hair cell regeneration. Moreover, we discuss advances and limitations of hair cell regeneration in the mature cochlea and their potential applications to human hearing loss.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping