PUBLICATION
Distinct antiviral activities of IFNφ1 and IFNφ4 in zebrafish
- Authors
- Chen, K., Tian, J., Shi, Y., Xie, T., Huang, W., Jia, Z., Zhang, Y., Yuan, G., Yan, H., Wang, J., Zou, J.
- ID
- ZDB-PUB-240121-6
- Date
- 2024
- Source
- Fish & shellfish immunology 146: 109396 (Journal)
- Registered Authors
- Keywords
- Antiviral response, Interferon, Virus, Zebrafish
- MeSH Terms
-
- Animals
- Cytokines/genetics
- Interferon Type I*/genetics
- Interferons/metabolism
- Perciformes*/metabolism
- Phosphorylation
- Zebrafish
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 38244820 Full text @ Fish Shellfish Immunol.
Citation
Chen, K., Tian, J., Shi, Y., Xie, T., Huang, W., Jia, Z., Zhang, Y., Yuan, G., Yan, H., Wang, J., Zou, J. (2024) Distinct antiviral activities of IFNφ1 and IFNφ4 in zebrafish. Fish & shellfish immunology. 146:109396.
Abstract
Interferons (IFNs) are a group of secreted cytokines that play a crucial role in antiviral immunity. Type I IFNs display functional disparities. In teleosts, type I IFNs are categorized into two subgroups containing one or two pairs of disulfide bonds. However, their functional differences have not been fully elucidated. In this study, we comparatively characterized the antiviral activities of zebrafish IFNφ1 and IFNφ4 belonging to the group I type I IFNs. It was found that ifnφ1 and ifnφ4 were differentially modulated during viral infection. Although both IFNφ1 and IFNφ4 activated JAK-STAT signaling pathway via CRFB1/CRFB5 receptor complex, IFNφ4 was less potent in inducing phosphorylation of STAT1a, STAT1b and STAT2 and the expression of antiviral genes than IFNφ1, thereby conferring weaker antiviral resistance of target cells. Taken together, our results provide insights into the functional divergence of type I IFNs in lower vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping