PUBLICATION
Understanding zebrafish sleep and wakefulness physiology as an experimental model for biomedical research
- Authors
- Singh, R., Sharma, D., Kumar, A., Singh, C., Singh, A.
- ID
- ZDB-PUB-231228-1
- Date
- 2023
- Source
- Fish physiology and biochemistry 50(2): 827-842 (Review)
- Registered Authors
- Keywords
- Hypocretin, Neurotransmitters, Orexin, REM/NREM, Sleep-wake cycle, Zebrafish
- MeSH Terms
-
- Animals
- Sleep/physiology
- Zebrafish*/physiology
- Biomedical Research*
- Mammals
- Models, Theoretical
- Hypothalamo-Hypophyseal System
- Circadian Rhythm/physiology
- Pituitary-Adrenal System
- Humans
- Wakefulness/physiology
- Orexins
- PubMed
- 38150068 Full text @ Fish Physiol. Biochem.
Citation
Singh, R., Sharma, D., Kumar, A., Singh, C., Singh, A. (2023) Understanding zebrafish sleep and wakefulness physiology as an experimental model for biomedical research. Fish physiology and biochemistry. 50(2):827-842.
Abstract
Sleep is a globally observable fact, or period of reversible distracted rest, that can be distinguished from arousal by various behavioral criteria. Although the function of sleep is an evolutionarily conserved behavior, its mechanism is not yet clear. The zebrafish (Danio rerio) has become a valuable model for neurobehavioral studies such as studying learning, memory, anxiety, and depression. It is characterized by a sleep-like state and circadian rhythm, making it comparable to mammals. Zebrafish are a good model for behavioral studies because they share genetic similarities with humans. A number of neurotransmitters are involved in sleep and wakefulness. There is a binding between melatonin and the hypocretin system present in zebrafish. The full understanding of sleep and wakefulness physiology in zebrafish is still unclear among researchers. Therefore, to make a clear understanding of the sleep/wake cycle in zebrafish, this article covers the mechanism involved behind it, and the role of the neuromodulator system followed by the mechanism of the HPA axis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping