PUBLICATION
Effusanin B Inhibits Lung Cancer by Prompting Apoptosis and Inhibiting Angiogenesis
- Authors
- Hou, J., Li, Y., Xing, H., Cao, R., Jin, X., Xu, J., Guo, Y.
- ID
- ZDB-PUB-231210-3
- Date
- 2023
- Source
- Molecules 28(23): (Journal)
- Registered Authors
- Keywords
- FAK, STAT3, angiogenesis, anti-tumor, diterpenoid, effusanin B, zebrafish
- MeSH Terms
-
- Lung Neoplasms*/metabolism
- Reactive Oxygen Species/metabolism
- Cell Proliferation
- Humans
- Zebrafish/metabolism
- STAT3 Transcription Factor/metabolism
- Cell Line, Tumor
- Apoptosis
- Signal Transduction
- Animals
- Carcinoma, Non-Small-Cell Lung*/drug therapy
- Carcinoma, Non-Small-Cell Lung*/pathology
- Angiogenesis
- PubMed
- 38067413 Full text @ Molecules
Citation
Hou, J., Li, Y., Xing, H., Cao, R., Jin, X., Xu, J., Guo, Y. (2023) Effusanin B Inhibits Lung Cancer by Prompting Apoptosis and Inhibiting Angiogenesis. Molecules. 28(23):.
Abstract
Cancer is one of the deadliest human diseases, causing high rates of illness and death. Lung cancer has the highest mortality rate among all malignancies worldwide. Effusanin B, a diterpenoid derived from Isodon serra, showed therapeutic potential in treating non-small-cell lung cancer (NSCLC). Further research on the mechanism indicated that effusanin B inhibited the proliferation and migration of A549 cells both in vivo and in vitro. The in vitro activity assay demonstrated that effusanin B exhibited significant anticancer activity. Effusanin B induced apoptosis, promoted cell cycle arrest, increased the production of reactive oxygen species (ROS), and altered the mitochondrial membrane potential (MMP). Based on mechanistic studies, effusanin B was found to inhibit the proliferation and migration of A549 cells by affecting the signal transducer and activator of transcription 3 (STAT3) and focal adhesion kinase (FAK) pathways. Moreover, effusanin B inhibited tumor growth and spread in a zebrafish xenograft model and demonstrated anti-angiogenic effects in a transgenic zebrafish model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping