PUBLICATION
TRAF3 gene regulates macrophage migration and activation by lung epithelial cells infected with Aspergillus fumigatus
- Authors
- Shang, S., He, D., Liu, C., Bao, X., Han, S., Wang, L.
- ID
- ZDB-PUB-231130-3
- Date
- 2023
- Source
- Microbiology spectrum 12(1): e0269923 (Journal)
- Registered Authors
- Keywords
- Aspergillus fumigatus, TRAF3, lung epithelial cells, macrophage, zebrafish
- MeSH Terms
-
- TNF Receptor-Associated Factor 3*/metabolism
- Humans
- Aspergillus fumigatus*/genetics
- Macrophages
- Epithelial Cells/microbiology
- Lung/microbiology
- Spores, Fungal/metabolism
- PubMed
- 38018974 Full text @ Microbiol Spectr
Citation
Shang, S., He, D., Liu, C., Bao, X., Han, S., Wang, L. (2023) TRAF3 gene regulates macrophage migration and activation by lung epithelial cells infected with Aspergillus fumigatus. Microbiology spectrum. 12(1):e0269923.
Abstract
Aspergillus fumigatus can infect immunocompromised individuals and cause chronic and fatal invasive fungal infections. A better understanding of the molecular mechanisms of A. fumigatus-host interactions may provide new references for disease treatment. In this study, we demonstrated that the TRAF3 gene plays an important role in the early infection of A. fumigatus by regulating the resistance of lung epithelial cells to A. fumigatus. Macrophages are the most abundant innate immune cells in the alveoli; however, few studies have reported on the interactions between lung epithelial cells and macrophages in response to A. fumigatus invasion. In our study, it was demonstrated that the TRAF3 gene reduces migration to macrophages and cytokine production by negatively regulating lung epithelial cell adhesion and internalization of A. fumigatus spores. Together, our results provide new insights into lung epithelial cell-macrophage interactions during A. fumigatus infection.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping