PUBLICATION
Bisphenol S remodels red blood cell membrane lipids by altering plasma lipid levels, causing the risk of venous thrombosis in SD rats and zebrafish embryos
- Authors
- Li, J., Li, Z., Zhu, Y., Peng, H., Du, Z., Ru, S., Wang, W.
- ID
- ZDB-PUB-231124-2
- Date
- 2023
- Source
- Environment International 182: 108331108331 (Journal)
- Registered Authors
- Keywords
- Bisphenol S, Rats, Red blood cells, Venous thrombosis, Zebrafish
- MeSH Terms
-
- Venous Thrombosis*
- Rats
- Humans
- Membrane Lipids/metabolism
- Zebrafish*/metabolism
- Erythrocyte Membrane
- Rats, Sprague-Dawley
- Animals
- PubMed
- 37995390 Full text @ Environ. Int.
Citation
Li, J., Li, Z., Zhu, Y., Peng, H., Du, Z., Ru, S., Wang, W. (2023) Bisphenol S remodels red blood cell membrane lipids by altering plasma lipid levels, causing the risk of venous thrombosis in SD rats and zebrafish embryos. Environment International. 182:108331108331.
Abstract
Bisphenol S (BPS) is a raw material that is used extensively in various manufacturing processes but possesses a high detection rate in human red blood cells (RBCs). Accordingly, BPS is a potential toxicant in disturbing the function of RBCs and causing RBC-related diseases. To date, the effects and mechanisms of BPS-induced RBC-related diseases have not been elucidated. Here, using different models, including rats, zebrafish embryos and RBCs, the underlying mechanism of RBC-related diseases induced by BPS was explored. The accumulation of BPS in tissue was colon > kidney > liver > plasma > testicle > heart > brain in SD rats orally administered BPS (10 and 50 mg/kg bw/day) for 32 days, which was similar in both 10 mg/kg bw/day and 50 mg/kg bw/day group. Rats given BPS orally developed hyperlipidemia and increased RBC membrane cholesterol, as well as changes in RBC morphology and function. Moreover, BPS at the concentrations measured in rats plasma caused oxidative stress and phosphatidylserine exposure in vitro RBCs. These combined factors led to RBC aggregation in blood and an increasing in the number of RBCs in the blood vessels of the liver in rats. The dynamic visual observation of RBCs in vein vessels of zebrafish embryos exposed to BPS at 0, 1, 10 and 100 μg/L further found that the flow of RBCs in the tail vein is slow or even immobile, posing the risk of venous thrombosis. The present study provides new insight into the links between environmental pollutants and venous thrombosis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping