PUBLICATION
Neuroprotective effect of plasmalogens on AlCl3-induced Alzheimer's disease zebrafish via acting on the regulatory network of ferroptosis, apoptosis and synaptic neurotransmission release with oxidative stress as the center
- Authors
- Zhang, J., Guo, S., Tao, R., Wang, F., Xie, Y., Wang, H., Ding, L., Shen, Y., Zhou, X., Feng, J., Shen, Q.
- ID
- ZDB-PUB-231120-8
- Date
- 2023
- Source
- Neuroscience letters 818: 137560 (Journal)
- Registered Authors
- Keywords
- Alzheimer's disease, Apoptosis, Ferroptosis, Oxidative stress, Plasmalogens, Synaptic neurotransmission release
- MeSH Terms
-
- Alzheimer Disease*/chemically induced
- Alzheimer Disease*/drug therapy
- Alzheimer Disease*/metabolism
- Animals
- Apoptosis
- Ferroptosis*
- Neuroprotective Agents*/pharmacology
- Oxidative Stress
- Plasmalogens/metabolism
- Plasmalogens/pharmacology
- Synaptic Transmission
- Zebrafish/metabolism
- PubMed
- 37979715 Full text @ Neurosci. Lett.
Citation
Zhang, J., Guo, S., Tao, R., Wang, F., Xie, Y., Wang, H., Ding, L., Shen, Y., Zhou, X., Feng, J., Shen, Q. (2023) Neuroprotective effect of plasmalogens on AlCl3-induced Alzheimer's disease zebrafish via acting on the regulatory network of ferroptosis, apoptosis and synaptic neurotransmission release with oxidative stress as the center. Neuroscience letters. 818:137560.
Abstract
Plasmalogens (Pls) are considered to play a potential role in the treatment of neurodegenerative diseases. In the present study, an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 was established to investigate whether the marine-derived Pls could alleviate cognitive impairments of AD zebrafish. Behavioral tests were carried out to assess the athletic ability. The transcriptional profiles of zebrafish in the control, AD model and AD_PLS group were compared and analyzed to determine the potential mechanisms of dietary Pls on AD. The study found that Pls could reverse athletic impairment in the AD zebrafish model, and the expression levels of genes related to ferroptosis, synaptic dysfunction and apoptosis were significantly altered between experimental groups. Further analysis showed that all of these genes were associated with oxidative stress (OS). These data suggest that healthy protective role of marine-derived Pls on AD zebrafish may result from inhibition of ferroptosis and neuronal apoptosis, restoring synaptic neurotransmission release, and reducing neuroinflammation. Among them, Oxidative stress is acted as the center to connect different regulation pathways. This study provides evidence to support the essential roles of OS in pathogenesis of AD, and the application of Pls in relieving AD.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping