PUBLICATION
The effects of valproic acid neurotoxicity on aggressive behavior in zebrafish autism model
- Authors
- Li, X., Feng, T., Lu, W.
- ID
- ZDB-PUB-231106-10
- Date
- 2023
- Source
- Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 275: 109783 (Journal)
- Registered Authors
- Keywords
- Behavior, Neurotoxicity, Valproic acid, Zebrafish
- MeSH Terms
-
- Aggression
- Animals
- Autism Spectrum Disorder*/chemically induced
- Autism Spectrum Disorder*/drug therapy
- Autism Spectrum Disorder*/genetics
- Autistic Disorder*/chemically induced
- Autistic Disorder*/genetics
- Behavior, Animal
- Disease Models, Animal
- Social Behavior
- Valproic Acid/toxicity
- Zebrafish
- PubMed
- 37926328 Full text @ Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Citation
Li, X., Feng, T., Lu, W. (2023) The effects of valproic acid neurotoxicity on aggressive behavior in zebrafish autism model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 275:109783.
Abstract
Valproic acid (VPA) is an effective drug, which is preferred for the treatments of epilepsy and various kinds of seizures. Nonetheless, VPA has many side effects associated with autism spectrum disorder (ASD). Therefore, we conducted molecular and behavior tests in adult proactive zebrafish after VPA exposure to investigate gene transcription changes, social behavior, aggression, anxiety and locomotion. Our findings revealed that VPA exposure generates ASD-like phenotypes and behaviors: genes associated with autism, such as adsl, mbd5 and shank3a altered; social interaction deficit. Further behavioral patterns suggest that VPA exposure induces decreases in aggression and increases the anxiety behavior and body cortisol significantly. VPA exposure did not affect locomotor activity in zebrafish. Additionally, we used correlative analyses to investigate the robustness between the ASD-related genes and the different behavior tests, results showed that ASD-related genes are negatively associated with aggressive behavior. Our study demonstrated that aggressive behavior assay is a better predictor of behavior for neurotoxicology of VPA.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping