PUBLICATION
Zebrafish as an emerging model to study estrogen receptors in neural development
- Authors
- Boueid, M.J., El-Hage, O., Schumacher, M., Degerny, C., Tawk, M.
- ID
- ZDB-PUB-230904-63
- Date
- 2023
- Source
- Frontiers in endocrinology 14: 12400181240018 (Review)
- Registered Authors
- Boueid, Marie-Jose, Degerny, Cindy, Tawk, Marcel
- Keywords
- GPER, estrogen (17β-estradiol), estrogen receptor - ESR, glia, neurogenesis, notch, oligodendrocyte (OL), zebrafish
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Estrogens
- Neurogenesis
- Receptors, Estrogen*/genetics
- Zebrafish*/genetics
- PubMed
- 37664862 Full text @ Front Endocrinol (Lausanne)
Citation
Boueid, M.J., El-Hage, O., Schumacher, M., Degerny, C., Tawk, M. (2023) Zebrafish as an emerging model to study estrogen receptors in neural development. Frontiers in endocrinology. 14:12400181240018.
Abstract
Estrogens induce several regulatory signals in the nervous system that are mainly mediated through estrogen receptors (ERs). ERs are largely expressed in the nervous system, yet the importance of ERs to neural development has only been elucidated over the last decades. Accumulating evidence shows a fundamental role for estrogens in the development of the central and peripheral nervous systems, hence, the contribution of ERs to neural function is now a growing area of research. The conservation of the structure of the ERs and their response to estrogens make the zebrafish an interesting model to dissect the role of estrogens in the nervous system. In this review, we highlight major findings of ER signaling in embryonic zebrafish neural development and compare the similarities and differences to research in rodents. We also discuss how the recent generation of zebrafish ER mutants, coupled with the availability of several transgenic reporter lines, its amenability to pharmacological studies and in vivo live imaging, could help us explore ER function in embryonic neural development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping