PUBLICATION
Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures
- Authors
- Wiśniewski, K., Antonowski, T., Juranek, J., Podlasz, P., Wojtkiewicz, J.
- ID
- ZDB-PUB-230429-61
- Date
- 2023
- Source
- International Journal of Molecular Sciences 24(8): (Journal)
- Registered Authors
- Podlasz, Piotr
- Keywords
- antiepileptic properties, epilepsy, scyllo-inositol, seizures, zebrafish
- MeSH Terms
-
- Animals
- Anticonvulsants*/adverse effects
- Epilepsy*/chemically induced
- Epilepsy*/drug therapy
- Larva
- Pentylenetetrazole/pharmacology
- Seizures/chemically induced
- Seizures/drug therapy
- Zebrafish
- PubMed
- 37108760 Full text @ Int. J. Mol. Sci.
Citation
Wiśniewski, K., Antonowski, T., Juranek, J., Podlasz, P., Wojtkiewicz, J. (2023) Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures. International Journal of Molecular Sciences. 24(8):.
Abstract
Epilepsy, with about 70 million affected people worldwide, is one of the biggest challenges of medicine today. It is estimated that about one-third of epileptic patients receive inadequate treatment. Inositols have proved effective in many disorders; hence, in the current study, we tested potential antiepileptic properties of scyllo-inositol (SCI)-one of the most common commercially available inositols-in zebrafish larvae with pentylenetetrazol-induced seizures. First, we studied the general effect of SCI on zebrafish motility, and then we tested SCI antiepileptic properties over short (1 h) and long (120 h) exposure protocols. Our results demonstrated that SCI alone does not reduce zebrafish motility regardless of the dose. We also observed that short-term exposure to SCI groups reduced PTZ-treated larva motility compared to controls (p < 0.05). In contrast, prolonged exposure did not produce similar results, likely due to the insufficient concentration of SCI given. Our results highlight the potential of SCI use in epilepsy treatment and warrant further clinical studies with inositols as potential seizure-reducing drugs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping