PUBLICATION
Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics
- Authors
- Strakosas, X., Biesmans, H., Abrahamsson, T., Hellman, K., Ejneby, M.S., Donahue, M.J., Ekström, P., Ek, F., Savvakis, M., Hjort, M., Bliman, D., Linares, M., Lindholm, C., Stavrinidou, E., Gerasimov, J.Y., Simon, D.T., Olsson, R., Berggren, M.
- ID
- ZDB-PUB-230224-46
- Date
- 2023
- Source
- Science (New York, N.Y.) 379: 795802795-802 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Electrodes
- Electronics*
- Polymers/chemistry
- Zebrafish*
- PubMed
- 36821679 Full text @ Science
Citation
Strakosas, X., Biesmans, H., Abrahamsson, T., Hellman, K., Ejneby, M.S., Donahue, M.J., Ekström, P., Ek, F., Savvakis, M., Hjort, M., Bliman, D., Linares, M., Lindholm, C., Stavrinidou, E., Gerasimov, J.Y., Simon, D.T., Olsson, R., Berggren, M. (2023) Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics. Science (New York, N.Y.). 379:795802795-802.
Abstract
Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible with living systems. The difference between static solid-state electronics and dynamic biological matter makes seamless integration of the two challenging. To address this incompatibility, we developed a method to dynamically create soft substrate-free conducting materials within the biological environment. We demonstrate in vivo electrode formation in zebrafish and leech models, using endogenous metabolites to trigger enzymatic polymerization of organic precursors within an injectable gel, thereby forming conducting polymer gels with long-range conductivity. This approach can be used to target specific biological substructures and is suitable for nerve stimulation, paving the way for fully integrated, in vivo-fabricated electronics within the nervous system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping