PUBLICATION
A molecular atlas of cell types and zonation in the brain vasculature
- Authors
- Vanlandewijck, M., He, L., Mäe, M.A., Andrae, J., Ando, K., Del Gaudio, F., Nahar, K., Lebouvier, T., Laviña, B., Gouveia, L., Sun, Y., Raschperger, E., Räsänen, M., Zarb, Y., Mochizuki, N., Keller, A., Lendahl, U., Betsholtz, C.
- ID
- ZDB-PUB-230123-7
- Date
- 2018
- Source
- Nature 554: 475480475-480 (Journal)
- Registered Authors
- Ando, Koji, Betsholtz, Christer, Mochizuki, Naoki, Raschperger, Elisabeth
- Keywords
- none
- MeSH Terms
-
- Animals
- Arteries/cytology
- Arterioles/cytology
- Blood Vessels/cytology*
- Brain/blood supply*
- Brain/cytology*
- Capillaries/cytology
- Endothelial Cells/classification*
- Female
- Fibroblasts/classification
- Male
- Mice
- Myocytes, Smooth Muscle/classification
- Organ Specificity
- Pericytes/classification
- Single-Cell Analysis
- Transcriptome
- Veins/cytology
- PubMed
- 29443965 Full text @ Nature
Citation
Vanlandewijck, M., He, L., Mäe, M.A., Andrae, J., Ando, K., Del Gaudio, F., Nahar, K., Lebouvier, T., Laviña, B., Gouveia, L., Sun, Y., Raschperger, E., Räsänen, M., Zarb, Y., Mochizuki, N., Keller, A., Lendahl, U., Betsholtz, C. (2018) A molecular atlas of cell types and zonation in the brain vasculature. Nature. 554:475480475-480.
Abstract
Cerebrovascular disease is the third most common cause of death in developed countries, but our understanding of the cells that compose the cerebral vasculature is limited. Here, using vascular single-cell transcriptomics, we provide molecular definitions for the principal types of blood vascular and vessel-associated cells in the adult mouse brain. We uncover the transcriptional basis of the gradual phenotypic change (zonation) along the arteriovenous axis and reveal unexpected cell type differences: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells. We also provide insight into pericyte organotypicity and define a population of perivascular fibroblast-like cells that are present on all vessel types except capillaries. Our work illustrates the power of single-cell transcriptomics to decode the higher organizational principles of a tissue and may provide the initial chapter in a molecular encyclopaedia of the mammalian vasculature.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping