PUBLICATION
Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis
- Authors
- Lai, S.L., Chien, A.J., Moon, R.T.
- ID
- ZDB-PUB-221110-8
- Date
- 2009
- Source
- Cell Research 19: 532-45 (Review)
- Registered Authors
- Lai, Shih-Lei (Ben)
- Keywords
- none
- MeSH Terms
-
- Cell Adhesion
- Cilia/metabolism
- Cytoskeleton/metabolism*
- Frizzled Receptors/metabolism*
- Humans
- Neoplasms/etiology
- Neoplasms/metabolism*
- Signal Transduction*
- Wnt Proteins/metabolism*
- beta Catenin/metabolism*
- rho GTP-Binding Proteins/metabolism
- PubMed
- 19365405 Full text @ Cell Res.
Citation
Lai, S.L., Chien, A.J., Moon, R.T. (2009) Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis. Cell Research. 19:532-45.
Abstract
Wnt/beta-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differentiation, survival, and adhesion. Beta-catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the possible roles of both beta-catenin-dependent and -independent signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and cilia/ciliogenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping