PUBLICATION
Motilin is a regulator of gastric contraction in Japanese fire belly newts (Cynops pyrrhogaster), in vitro studies using isolated gastrointestinal strips of newts, rabbits, and chickens
- Authors
- Zhang, S., Kaiya, H., Kitazawa, T.
- ID
- ZDB-PUB-221018-46
- Date
- 2022
- Source
- General and comparative endocrinology 330: 114140 (Journal)
- Registered Authors
- Keywords
- Amphibian, Japanese fire belly newt, Urodelean, gastrointestinal contraction, motilin
- MeSH Terms
-
- Gastrointestinal Tract*/physiology
- Stomach
- Humans
- Zebrafish
- Salamandridae
- Chickens
- Rabbits
- Animals
- Motilin*/chemistry
- Muscle Contraction*
- Gastrointestinal Motility*
- PubMed
- 36228737 Full text @ Gen. Comp. Endocrinol.
Citation
Zhang, S., Kaiya, H., Kitazawa, T. (2022) Motilin is a regulator of gastric contraction in Japanese fire belly newts (Cynops pyrrhogaster), in vitro studies using isolated gastrointestinal strips of newts, rabbits, and chickens. General and comparative endocrinology. 330:114140.
Abstract
The effects of newt motilin on the contractility of the isolated gastrointestinal (GI) tract from Japanese fire belly newts (newt) were examined to clarify whether motilin regulates GI motility in urodele amphibians. In addition, contractile responsiveness to motilins from seven species of vertebrates (human, chicken, turtle, alligator, axolotol, newt and zebrafish) were compared in GI preparations from three different animals (rabbit duodenum, chicken ileum and newt stomach) to determine the species-specific action of motilin. Newt motilin (10-10 M - 10-6 M) caused a contraction of cognate gastric strips, while the upper, middle, and lower intestinal strips were insensitive. The rank order of motilins for contractile activity in newt gastric strips was newt > alligator > axolotol > chicken > turtle > human >> zebrafish. On the other hand, newt motilin caused a weak contraction in the rabbit duodenum (human > alligator = chicken > turtle > axolotol ≧ newt > zebrafish), and it was ineffective in the chicken ileum (chicken > turtle = alligator > human >> newt, axolotol and zebrafish). This study demonstrates that motilin induces contraction in the GI tract of a urodele amphibian, the newt, in a region (stomach)-specific manner and further indicates that a ligand-receptor interaction of the motilin system is a species-specific manner probably due to differences in the amino acid sequence of motilin.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping