PUBLICATION
Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration
- Authors
- Hui, S.P., Sugimoto, K., Sheng, D.Z., Kikuchi, K.
- ID
- ZDB-PUB-220907-2
- Date
- 2022
- Source
- Frontiers in immunology 13: 981000 (Journal)
- Registered Authors
- Hui, Subhra Prakash, Kikuchi, Kazu, Sheng, Delicia
- Keywords
- Tregs, blastema, fin regeneration, growth factors, zebrafish
- MeSH Terms
-
- Animals
- Cell Proliferation
- Signal Transduction/genetics
- T-Lymphocytes, Regulatory*/metabolism
- Zebrafish*/genetics
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 36059461 Full text @ Front Immunol
Citation
Hui, S.P., Sugimoto, K., Sheng, D.Z., Kikuchi, K. (2022) Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration. Frontiers in immunology. 13:981000.
Abstract
The role of T cells in appendage regeneration remains unclear. In this study, we revealed an important role for regulatory T cells (Tregs), a subset of T cells that regulate tolerance and tissue repair, in the epimorphic regeneration of zebrafish caudal fin tissue. Upon amputation, fin tissue-resident Tregs infiltrate into the blastema, a population of progenitor cells that produce new fin tissues. Conditional genetic ablation of Tregs attenuates blastemal cell proliferation during fin regeneration. Blastema-infiltrating Tregs upregulate the expression of igf2a and igf2b, and pharmacological activation of IGF signaling restores blastemal proliferation in Treg-ablated zebrafish. These findings further extend our understandings of Treg function in tissue regeneration and repair.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping