PUBLICATION
Bacterial-agglutinating and opsonic activities of RIPK1 in zebrafish
- Authors
- Duan, H., Yang, S., Zhang, X., Ji, G.
- ID
- ZDB-PUB-220819-12
- Date
- 2022
- Source
- Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 261: 109443 (Journal)
- Registered Authors
- Keywords
- A pattern-recognition receptor, Lectin-like activity, RIPK1, Zebrafish
- MeSH Terms
-
- Animals
- Gram-Negative Bacteria
- Immunity, Innate
- Lectins, C-Type
- Lipopolysaccharides*/pharmacology
- Zebrafish*
- PubMed
- 35981661 Full text @ Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Citation
Duan, H., Yang, S., Zhang, X., Ji, G. (2022) Bacterial-agglutinating and opsonic activities of RIPK1 in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 261:109443.
Abstract
Many studies have demonstrated that receptor interacting protein kinase-1 acts as a crucial mediator in the regulation of immune response, but evidence remains lacking for its direct interaction with bacteria. In this study, we found that challenge with lipopolysaccharide and lipoteichoic acid resulted in a significantly increased transcriptional expression of receptor interacting protein kinase-1 in zebrafish, suggesting the receptor interacting protein kinase-1 is implicated in anti-infectious responses. In accordance, we found that recombinant receptor interacting protein kinase-1 was not only able to bind to Gram-negative and -positive bacteria via interaction with lipopolysaccharide and lipoteichoic acid, but also agglutinate both Gram-negative and -positive bacteria in a Ca2+-dependent manner.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping