PUBLICATION
Identification of zebrafish PLEKHF2 presents in egg/embryos as an antibacterial protein
- Authors
- Ren, Y., Wang, C., Wang, H., Chang, Q., Guo, D., Wang, X.
- ID
- ZDB-PUB-220722-23
- Date
- 2022
- Source
- Fish & shellfish immunology 127: 925-932 (Journal)
- Registered Authors
- Keywords
- Antibacterial activity, PLEKHF2 proteins, Pattern recognition receptor
- MeSH Terms
-
- Animals
- Anti-Bacterial Agents/pharmacology
- Bacteria/metabolism
- Lipopolysaccharides/metabolism
- Receptors, Pattern Recognition
- Zebrafish*
- Zebrafish Proteins*/metabolism
- PubMed
- 35863537 Full text @ Fish Shellfish Immunol.
Citation
Ren, Y., Wang, C., Wang, H., Chang, Q., Guo, D., Wang, X. (2022) Identification of zebrafish PLEKHF2 presents in egg/embryos as an antibacterial protein. Fish & shellfish immunology. 127:925-932.
Abstract
PLEKHF2 proteins are widespread in animals, but their functions and mechanisms remain poorly defined. Here we clearly demonstrate that PLEKHF2 is a newly identified present abundantly in the eggs/embryos of zebrafish. We also show that recombinant PLEKHF2 acts as a pattern recognition receptor capable of identifying the bacterial signature molecule PGN, LPS, and LTA, binding the bacteria, and functions as an antibacterial effector directly killing the bacteria. In brief, these results indicate that PLEKHF2 is an antibacterial protein, a novel role assigned to PLEKHF2 proteins.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping