PUBLICATION
Gill developmental program in the teleost mandibular arch
- Authors
- Thiruppathy, M., Fabian, P., Gillis, J.A., Crump, J.G.
- ID
- ZDB-PUB-220629-5
- Date
- 2022
- Source
- eLIFE 11: (Journal)
- Registered Authors
- Keywords
- Gill, Pseudobranch, cranial neural crest, developmental biology, evolutionary biology, jaw, mandibular arch, zebrafish
- MeSH Terms
-
- Animals
- Biological Evolution*
- Branchial Region
- Gills*
- Jaw
- Zebrafish
- PubMed
- 35762575 Full text @ Elife
Citation
Thiruppathy, M., Fabian, P., Gillis, J.A., Crump, J.G. (2022) Gill developmental program in the teleost mandibular arch. eLIFE. 11.
Abstract
Whereas no known living vertebrate possesses gills derived from the jaw-forming mandibular arch, it has been proposed that the jaw arose through modifications of an ancestral mandibular gill. Here, we show that the zebrafish pseudobranch, which regulates blood pressure in the eye, develops from mandibular arch mesenchyme and first pouch epithelia and shares gene expression, enhancer utilization, and developmental gata3 dependence with the gills. Combined with work in chondrichthyans, our findings in a teleost fish point to the presence of a mandibular pseudobranch with serial homology to gills in the last common ancestor of jawed vertebrates, consistent with a gill origin of vertebrate jaws.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping