PUBLICATION
High glucose-induced ROS-accumulation in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis
- Authors
- Li, Y., Chen, Q., Liu, Y., Bi, L., Jin, L., Xu, K., Peng, R.
- ID
- ZDB-PUB-220522-3
- Date
- 2022
- Source
- Apoptosis : an international journal on programmed cell death 27(7-8): 509-520 (Journal)
- Registered Authors
- Keywords
- Apoptosis, Diabetes, Mitochondria, ROS, Zebrafish
- MeSH Terms
-
- Animals
- Apoptosis*
- Embryo, Nonmammalian/metabolism
- Glucose/metabolism
- Glucose/pharmacology
- Humans
- Larva/metabolism
- Mitochondria/metabolism
- Oxidative Stress
- Reactive Oxygen Species/metabolism
- Zebrafish*
- PubMed
- 35596834 Full text @ Apoptosis
Citation
Li, Y., Chen, Q., Liu, Y., Bi, L., Jin, L., Xu, K., Peng, R. (2022) High glucose-induced ROS-accumulation in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis. Apoptosis : an international journal on programmed cell death. 27(7-8):509-520.
Abstract
In recent decades, diabetes mellitus has become a major chronic disease threatening human health worldwide, and the age of patients tends to be younger; however, the pathogenesis remains unclear, resulting in many difficulties in its treatment. As an ideal model animal, zebrafish can simulate the processes of human diabetes well. In this study, we successfully established a model of diabetic zebrafish larvae in a previous work. Furthermore, transcriptome analysis was completed, and the results suggested that 10.59% of differentially expressed genes (DEGs) related to the apoptosis pathway need to be considered. Then, glucose-induced developmental toxicity, reactive oxygen species (ROS) accumulation, antioxidant system function, apoptosis and mitochondrial dysfunction were measured in zebrafish larvae. We hope that this study will provide valuable reference information for type 2 juvenile diabetes treatment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping