PUBLICATION
PLAAT1 promotes p53 degradation via autophagy-lysosome pathway in zebrafish
- Authors
- Zhao, X., Huang, W., Guo, J., Ji, N., Feng, J., Shi, Y., Chen, K., Zou, J.
- ID
- ZDB-PUB-220510-6
- Date
- 2022
- Source
- Fish & shellfish immunology 125: 48-53 (Journal)
- Registered Authors
- Keywords
- Apoptosis, Autophagy, Phospholipase A/acyltransferases, Protein interaction, Zebrafish, p53
- MeSH Terms
-
- Animals
- Apoptosis
- Autophagy/genetics
- Lysosomes/metabolism
- Signal Transduction
- Tumor Suppressor Protein p53*/genetics
- Tumor Suppressor Protein p53*/metabolism
- Zebrafish*/genetics
- Zebrafish*/metabolism
- PubMed
- 35526800 Full text @ Fish Shellfish Immunol.
Citation
Zhao, X., Huang, W., Guo, J., Ji, N., Feng, J., Shi, Y., Chen, K., Zou, J. (2022) PLAAT1 promotes p53 degradation via autophagy-lysosome pathway in zebrafish. Fish & shellfish immunology. 125:48-53.
Abstract
PLAAT1 belongs to the PLAAT family and plays regulatory roles in cell growth, tumor suppression and phospholipid metabolism. However, whether PLAAT1 is involved in p53 mediated signaling has not been investigated. Here, we report that PLAAT1 promotes degradation of p53 in zebrafish. We found that the plaat1 gene was constitutively expressed in tissues including liver, kidney, spleen, intestine, eye and brain, with relative higher expression levels detected in the brain and eye. Overexpression of plaat1 led to inhibition of p53 and tnfα mRNA expression. Furthermore, it was shown that PLAAT1 interacted with p53 to facilitate p53 degradation via autophagy-lysosome dependent pathway. Our work indicates that PLAAT1 is involved in the interplay between p53 mediated cellular responses and autophagy.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping