PUBLICATION
Developmental and behavioral toxicity assessment of glyphosate and its main metabolite aminomethylphosphonic acid (AMPA) in zebrafish embryos/larvae
- Authors
- Ivantsova, E., Wengrovitz, A.S., Souders, C.L., Martyniuk, C.J.
- ID
- ZDB-PUB-220505-12
- Date
- 2022
- Source
- Environmental Toxicology and Pharmacology 93: 103873 (Journal)
- Registered Authors
- Keywords
- agrochemical, behavior, fungicide, mitochondria, neurotoxicity
- MeSH Terms
-
- Animals
- Electron Transport Complex IV
- Glycine/analogs & derivatives
- Herbicides*/toxicity
- Larva
- Organophosphonates
- RNA, Messenger
- Zebrafish*
- alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology
- PubMed
- 35504511 Full text @ Environ. Toxicol. Pharmacol.
- CTD
- 35504511
Citation
Ivantsova, E., Wengrovitz, A.S., Souders, C.L., Martyniuk, C.J. (2022) Developmental and behavioral toxicity assessment of glyphosate and its main metabolite aminomethylphosphonic acid (AMPA) in zebrafish embryos/larvae. Environmental Toxicology and Pharmacology. 93:103873.
Abstract
The relative toxicity of glyphosate (GLY) and its metabolite aminomethylphosphonic acid (AMPA) to zebrafish were compared. Embryos/larvae were exposed to one dose of either GLY (0.1, 1, or 10μM), AMPA (0.1, 1, or 10μM), or a 1μM mixture for 7-days post-fertilization. Survival, success of hatch, and deformity frequency were not different from controls. Neither chemical induced reactive oxygen species in larval fish. GLY increased superoxide dismutase 2 mRNA in larvae while AMPA increased catalase and superoxide dismutase 1 in a concentration-specific manner. GLY increased cytochrome c oxidase subunit 4 isoform 1 and citrate synthase mRNA in larvae while AMPA decreased cytochrome c oxidase I and increased 3-hydroxyacyl CoA dehydrogenase transcripts. Hyperactivity was noted in fish treated with GLY, but not AMPA nor the mixture. Anxiety-like behaviors were absent with exposure to GLY or AMPA. GLY and AMPA may exert differing effects at the molecular and behavioral level.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping