PUBLICATION
Construction of inulin-based selenium nanoparticles to improve the antitumor activity of an inulin-type fructan from chicory
- Authors
- Shi, L., Li, Y., Zhang, S., Gong, X., Xu, J., Guo, Y.
- ID
- ZDB-PUB-220427-5
- Date
- 2022
- Source
- International journal of biological macromolecules 210: 261-270 (Journal)
- Registered Authors
- Keywords
- Anti-tumor activity, Inulin, Selenium nanoparticles
- MeSH Terms
-
- Animals
- Neoplasms*
- Nanoparticles*
- Selenium*/pharmacology
- Cichorium intybus*
- Fructans/pharmacology
- Inulin/pharmacology
- Zebrafish
- PubMed
- 35469953 Full text @ Int. J. Biol. Macromol.
Citation
Shi, L., Li, Y., Zhang, S., Gong, X., Xu, J., Guo, Y. (2022) Construction of inulin-based selenium nanoparticles to improve the antitumor activity of an inulin-type fructan from chicory. International journal of biological macromolecules. 210:261-270.
Abstract
Cancer has become one of the leading causes of death worldwide. It is urgent to develop new antitumor drugs with high efficiency and low toxicity. In this study, the inulin-type fructan CIP70-1 was purified and characterized from chicory and showed weak antitumor activity. To improve its antitumor effects, inulin-based selenium nanoparticles (CIP-SeNPs) were constructed and characterized. CIP-SeNPs were spherical nanoparticles (60 nm) that remained stable in water for more than 3 months. A cellular antitumor assay revealed that CIP-SeNPs had stronger inhibitory effects on cancer cells (MCF-7, A549, and HepG2) than CIP70-1 alone. Furthermore, the in vivo antitumor effects of CIP-SeNPs were confirmed using zebrafish models. The results showed that CIP-SeNPs significantly inhibited the proliferation and migration of tumors as well as the angiogenesis of transgenic zebrafish in the concentration range of 1-4 μg/mL.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping